Browsing Centre for Cell Biology and Cutaneous Research by Title
Now showing items 101-120 of 380
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Downregulation of class II phosphoinositide 3-kinase PI3K-C2β delays cell division and potentiates the effect of docetaxel on cancer cell growth.
(BMC (part of Springer Nature), 2019-11-21)BACKGROUND: Alteration of signalling pathways regulating cell cycle progression is a common feature of cancer cells. Several drugs targeting distinct phases of the cell cycle have been developed but the inability of many ... -
Dysfunctional Skin-Derived Glucocorticoid Synthesis Is a Novel Pathogenic Mechanism of Psoriasis
(Elsevier, 2017-03-28)Glucocorticoids (GC) are the primary steroids that regulate inflammation and have been exploited therapeutically in inflammatory skin diseases. Despite the broad-spectrum therapeutic use of GC the biochemical rationale ... -
Early growth response 2 (EGR2) is a novel regulator of the senescence programme.
(2021-02-06)Senescence, a state of stable growth arrest, plays an important role in ageing and age-related diseases in vivo. Although the INK4/ARF locus is known to be essential for senescence programmes, the key regulators driving ... -
Effects of Cetuximab and Erlotinib on the behaviour of cancer stem cells in head and neck squamous cell carcinoma.
(2018-03-02)The therapeutic responses of many solid tumours to chemo- and radio-therapies are far from fully effective but therapies targeting malignancy-related cellular changes show promise for further control. In head and neck ... -
Embigin is a fibronectin receptor that affects sebaceous gland differentiation and metabolism.
(2022-06-20)Stem cell renewal and differentiation are regulated by interactions with the niche. Although multiple cell populations have been identified in distinct anatomical compartments, little is known about niche-specific molecular ... -
An enlarging nodule on the shin.
(2018-07)