Browsing Centre for Tumour Biology by Title
Now showing items 97-116 of 372
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Evolution via somatic genetic variation in modular species
(2021-09-01) -
Evolutionary dynamics of neoantigens in growing tumours
(2019-01-31)ABSTRACT Cancer evolution is driven by the acquisition of somatic mutations that provide cells with a beneficial phenotype in a changing microenvironment. However, mutations that give rise to neoantigens, novel cancer–specific ... -
The evolutionary landscape of colorectal tumorigenesis
(2018-10)The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant) remain largely undetermined. Using multi-region genome and exome sequencing of 24 benign and malignant colorectal tumours, ... -
Exploiting evolutionary steering to induce collateral drug sensitivity in cancer
(Springer Science and Business Media LLC, 2020-12) -
A faecal microbiota signature with high specificity for pancreatic cancer.
(2022-07)BACKGROUND: Recent evidence suggests a role for the microbiome in pancreatic ductal adenocarcinoma (PDAC) aetiology and progression. OBJECTIVE: To explore the faecal and salivary microbiota as potential diagnostic biomarkers. ... -
Fibroblast growth factor family as a potential target in the treatment of hepatocellular carcinoma.
(2014)Hepatocellular cancer (HCC) is currently the third leading cause of cancer death worldwide. The prognosis of patients diagnosed with late-stage disease is dismal due to high resistance to conventional systemic therapies. ...