Browsing Centre for Tumour Biology by Title
Now showing items 181-200 of 372
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Lipid Metabolism at the Nexus of Diet and Tumor Microenvironment
(Elsevier, 2019-11-01)Obesity is a leading contributing factor to cancer development worldwide. Epidemiological evidence suggests that diet affects cancer risk and also substantially alters therapeutic outcome. Therefore, studying the impact ... -
LiquidCNA: Tracking subclonal evolution from longitudinal liquid biopsies using somatic copy number alterations.
(2021-08-20)Cell-free DNA (cfDNA) measured via liquid biopsies provides a way for minimally invasive monitoring of tumor evolutionary dynamics during therapy. Here we present liquidCNA, a method to track subclonal evolution from ... -
Low health literacy predicts decline in physical function among older adults: Findings from the LitCog cohort study
(2015-01-01)Background: Limited health literacy is associated with worse physical function in cross-sectional studies. We aimed to determine if health literacy is a risk factor for decline in physical function among older adults. ... -
Lymphoepithelial Cyst of the Pancreas.
(2016)Lymphoepithelial cyst (LEC) of the pancreas is an extremely rare, benign pancreatic cystic lesion that is difficult to differentiate preoperatively from other cystic pancreatic lesions. LEC may have malignant potential. ... -
Measuring cancer evolution from the genome
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Measuring Clonal Evolution in Cancer with Genomics.
(2019-08-31)Cancers originate from somatic cells in the human body that have accumulated genetic alterations. These mutations modify the phenotype of the cells, allowing them to escape the homeostatic regulation that maintains normal ... -
Measuring single cell divisions in human cancers from multi-region sequencing data
(2019-02-25)Abstract Cancer is driven by complex evolutionary dynamics involving billions of cells. Increasing effort has been dedicated to sequence single tumour cells, but obtaining robust measurements remains challenging. Here we ... -
Measuring single cell divisions in human tissues from multi-region sequencing data.
(Nature Research (part of Springer Nature), 2020-02-25)Both normal tissue development and cancer growth are driven by a branching process of cell division and mutation accumulation that leads to intra-tissue genetic heterogeneity. However, quantifying somatic evolution in ... -
Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios
(2019-06-05)Abstract The distribution of fitness effects (DFE) defines how new mutations spread through an evolving population. The ratio of non-synonymous to synonymous mutations (dN/dS) has become a popular method to detect selection ... -
Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios.
(eLife Sciences Publications Ltd, 2020-03-30)The distribution of fitness effects (DFE) defines how new mutations spread through an evolving population. The ratio of non-synonymous to synonymous mutations (dN/dS) has become a popular method to detect selection in ...