Browsing Centre for Tumour Biology by Title
Now showing items 87-106 of 374
-
Endothelial Jagged1 promotes solid tumor growth through both pro-angiogenic and angiocrine functions
(Impact Journals, LLC, 2015-06-08)Angiogenesis is an essential process required for tumor growth and progression. The Notch signaling pathway has been identified as a key regulator of the neo-angiogenic process. Jagged-1 (Jag1) is a Notch ligand required ... -
Evolution of Premalignant Disease
(2017-12) -
Evolution via somatic genetic variation in modular species
(2021-09-01) -
Evolutionary dynamics of neoantigens in growing tumours
(2019-01-31)ABSTRACT Cancer evolution is driven by the acquisition of somatic mutations that provide cells with a beneficial phenotype in a changing microenvironment. However, mutations that give rise to neoantigens, novel cancer–specific ... -
The evolutionary landscape of colorectal tumorigenesis
(2018-10)The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant) remain largely undetermined. Using multi-region genome and exome sequencing of 24 benign and malignant colorectal tumours, ... -
Exploiting evolutionary steering to induce collateral drug sensitivity in cancer
(Springer Science and Business Media LLC, 2020-12)