DNA METHYLATION ANALYSIS OF PAEDIATRIC LOW-GRADE ASTROCYTOMAS IDENTIFIES A TUMOUR-SPECIFIC SIGNATURE AT A SET OF ENHANCERS
Abstract
Background/Objectives: Low-grade gliomas (LGGs) are the most common brain
tumours in children, and are dominated by pilocytic and diffuse astrocytomas (WHO
grades I and II, respectively). Although most of the genetic changes observed in LGGs
converge on the MAPK/ERK signalling pathway, there is heterogeneity in clinical
behaviour with diffuse astrocytomas having a significantly worse outcome than
pilocytic astrocytomas. To improve our understanding of the molecular origins of
paediatric LGGs, we have conducted a genome-wide study of DNA methylation in a
large, well-characterised group of tumours.
Authors
Sheer, D; Jeyapalan, J; Doctor, GT; Jones, TA; Alberman, SN; Tep, A; Haria, CM; Schwalbe, EC; Clifford, SC; Tatevossian, RG; Qaddoumi, I; Ellison, DWCollections
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