DNA METHYLATION ANALYSIS OF PAEDIATRIC LOW-GRADE ASTROCYTOMAS IDENTIFIES A TUMOUR-SPECIFIC SIGNATURE AT A SET OF ENHANCERS
S283 - S284
MetadataShow full item record
Background/Objectives: Low-grade gliomas (LGGs) are the most common brain tumours in children, and are dominated by pilocytic and diffuse astrocytomas (WHO grades I and II, respectively). Although most of the genetic changes observed in LGGs converge on the MAPK/ERK signalling pathway, there is heterogeneity in clinical behaviour with diffuse astrocytomas having a significantly worse outcome than pilocytic astrocytomas. To improve our understanding of the molecular origins of paediatric LGGs, we have conducted a genome-wide study of DNA methylation in a large, well-characterised group of tumours.