Centre for Molecular Oncology: Recent submissions
Now showing items 61-80 of 272
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Spotlight on the Replisome: Aetiology of DNA Replication-Associated Genetic Diseases.
(2020-10-08)Human development and tissue homeostasis depend on the regulated control of cellular proliferation and differentiation. DNA replication is essential to couple genome duplication and cell division with the establishment and ... -
A genome-wide RNAi screen identifies the SMC5/6 complex as a non-redundant regulator of a Topo2a-dependent G2 arrest
(Oxford University Press on behalf of Nucleic Acids Research, 2019-04-08) -
A cancer-associated, genome protective programme engaging PKCε.
(2020-12)Associated with their roles as targets for tumour promoters, there has been a long-standing interest in how members of the protein kinase C (PKC) family act to modulate cell growth and division. This has generated a great ... -
Mitotic catenation is monitored and resolved by a PKCε-regulated pathway.
(2014-12-08)Exit from mitosis is controlled by silencing of the spindle assembly checkpoint (SAC). It is important that preceding exit, all sister chromatid pairs are correctly bioriented, and that residual catenation is resolved, ... -
Phase II Study of Arginine Deprivation Therapy With Pegargiminase in Patients With Relapsed Sensitive or Refractory Small-cell Lung Cancer.
(Elsevier, 2020-11)BACKGROUND: Pre-clinical studies indicated that arginine-deprivation therapy using pegylated arginine deiminase (pegargiminase, ADI-PEG 20) may be effective in patients with argininosuccinate synthetase 1 (ASS1)-deficient ... -
Immunology in the Era of Single-Cell Technologies
(Annual Reviews, 2020-02-19)