Centre for Molecular Oncology: Recent submissions
Now showing items 41-60 of 272
-
A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer.
(2021-02-01)BACKGROUND: Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% ... -
Platelet Microparticles Induce Endoplasmic Reticulum Stress in The Endothelium Through Delivery of the miRNA Let-7a
(2019-04)Meeting abstract P10 from BSCR Autumn Meeting -
Developmental cell programs are co-opted in inflammatory skin disease.
(AAAS, 2021-01-22)The skin confers biophysical and immunological protection through a complex cellular network established early in embryonic development. We profiled the transcriptomes of more than 500,000 single cells from developing human ... -
The RNA-binding protein hnRNPA2 regulates β-catenin protein expression and is overexpressed in prostate cancer.
(Taylor & Francis, 2014)INTRODUCTION: The RNA-binding protein hnRNPA2 (HNRNPA2B1) is upregulated in cancer, where it controls alternative pre-mRNA splicing of cancer-relevant genes. Cytoplasmic hnRNPA2 is reported in aggressive cancers, but is ... -
Identification of a candidate prognostic gene signature by transcriptome analysis of matched pre- and post-treatment prostatic biopsies from patients with advanced prostate cancer.
(BioMed Central, 2014-12-18)BACKGROUND: Although chemotherapy for prostate cancer (PCa) can improve patient survival, some tumours are chemo-resistant. Tumour molecular profiles may help identify the mechanisms of drug action and identify potential ... -
Androgen-regulation of the protein tyrosine phosphatase PTPRR activates ERK1/2 signalling in prostate cancer cells.
(BioMed Central, 2015-01-16)BACKGROUND: Androgens drive the onset and progression of prostate cancer (PCa) via androgen receptor (AR) signalling. The principal treatment for PCa is androgen deprivation therapy, although the majority of patients ... -
The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7.
(2015-08-27)Castration-resistant (CR) prostate cancer (PCa) partly arises due to persistence of androgen receptor (AR) transcriptional activity in the absence of cognate ligand. An emerging mechanism underlying the CRPCa phenotype and ... -
A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation.
(Impact Journals, 2013-10-13)TSC2 (Tuberous sclerosis complex 2) is an important tumour suppressor gene, mutations within which are linked to the development of tuberous sclerosis and implicated in multiple tumour types. TSC2 protein complexes with ... -
Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy.
(2021-01)BACKGROUND: Immunotherapy with checkpoint inhibitors has shown impressive results in patients with melanoma, but still many do not benefit from this line of treatment. A lack of tumor-infiltrating T cells is a common reason ... -
Syrian Hamster as an Animal Model for the Study on Infectious Diseases
(Frontiers Media, 2019-10-01)Infectious diseases still remain one of the biggest challenges for human health. In order to gain a better understanding of the pathogenesis of infectious diseases and develop effective diagnostic tools, therapeutic ... -
The potential of brentuximab vedotin, alone or in combination with current clinical therapies, in the treatment of testicular germ cell tumors
(e-Century Publishing Corporation, 2019) -
Resolving the fibrotic niche of human liver cirrhosis at single-cell level
(Springer Nature, 2019-11-21)Liver cirrhosis is a major cause of death worldwide and is characterized by extensive fibrosis. There are currently no effective antifibrotic therapies available. To obtain a better understanding of the cellular and molecular ... -
Single-agent carboplatin AUC10 in metastatic seminoma: A multi-centre UK study of 216 patients.
(Elsevier Ltd., 2020-10-08)BACKGROUND: Radiotherapy and cisplatin-based combination chemotherapy are accepted standard-of-care treatments for metastatic seminoma with excellent survival outcomes but with established short- and long-term morbidity. ... -
Centrosome amplification mediates small extracellular vesicles secretion via lysosome disruption
(2020-08-20)Summary Bidirectional communication between cells and their surrounding environment is critical in both normal and pathological settings. Extracellular vesicles (EVs), which facilitate the horizontal transfer of molecules ...