A cancer-associated, genome protective programme engaging PKCε.
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Volume
78
Pagination
100759 - ?
DOI
10.1016/j.jbior.2020.100759
Journal
Advances in Biological Regulation
Metadata
Show full item recordAbstract
Associated with their roles as targets for tumour promoters, there has been a long-standing interest in how members of the protein kinase C (PKC) family act to modulate cell growth and division. This has generated a great deal of observational data, but has for the most part not afforded clear mechanistic insights into the control mechanisms at play. Here, we review the roles of PKCε in protecting transformed cells from non-disjunction. In this particular cell cycle context, there is a growing understanding of the pathways involved, affording biomarker and interventional insights and opportunities.