Centre for Molecular Oncology: Recent submissions
Now showing items 81-100 of 272
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Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis.
(2020-09-21)Psoriatic arthritis (PsA) is a debilitating immune-mediated inflammatory arthritis of unknown pathogenesis commonly affecting patients with skin psoriasis. Here we use complementary single-cell approaches to study leukocytes ... -
Decoding human fetal liver haematopoiesis
(2019-10-17) -
Specific mechanisms of chromosomal instability indicate therapeutic sensitivities in high-grade serous ovarian carcinoma.
(2020-09-30)Chromosomal instability (CIN) comprises continual gain and loss of chromosomes or parts of chromosomes and occurs in the majority of cancers, often conferring poor prognosis. Due to a scarcity of functional studies and ... -
PKCɛ switches Aurora B specificity to exit the abscission checkpoint.
(2016-12-22)The 'NoCut', or Aurora B abscission checkpoint can be activated if DNA is retained in the cleavage furrow after completion of anaphase. Checkpoint failure leads to incomplete abscission and a binucleate outcome. These ... -
Spatiotemporal immune zonation of the human kidney
(2019-09-27) -
Author Correction: The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition.
(2020-06-03)An amendment to this paper has been published and can be accessed via a link at the top of the paper.