Centre for Molecular Oncology: Recent submissions
Now showing items 21-40 of 272
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A cohort study of 30 day mortality after NON-EMERGENCY surgery in a COVID-19 cold site.
(2020-12)BACKGROUND: Two million non-emergency surgeries are being cancelled globally every week due to the COVID-19 pandemic, which will have a major impact on patients and healthcare systems. METHODS: During the peak of the ... -
A novel vaccinia virus enhances anti-tumor efficacy and promotes a long-term anti-tumor response in a murine model of colorectal cancer
(Elsevier (Cell Press), 2021-03-26)Colorectal cancer (CRC) is one of the leading causes of mortality and morbidity in the world, and there remains an urgent need to develop long-lasting therapies to treat CRC and prevent recurrence in patients. Oncolytic ... -
Chloroxine overrides DNA damage tolerance to restore platinum sensitivity in high-grade serous ovarian cancer
(Springer Nature, 2021-04-14)High-grade serous cancer (HGSC) accounts for ~67% of all ovarian cancer deaths. Although initially sensitive to platinum chemotherapy, resistance is inevitable and there is an unmet clinical need for novel therapies that ... -
Nivolumab versus placebo in patients with relapsed malignant mesothelioma (CONFIRM): a multicentre, double-blind, randomised, phase 3 trial.
(Elsevier, 2021-10-14)BACKGROUND: No phase 3 trial has yet shown improved survival for patients with pleural or peritoneal malignant mesothelioma who have progressed following platinum-based chemotherapy. The aim of this study was to assess the ... -
Phase 1, pharmacogenomic, dose-expansion study of pegargiminase plus pemetrexed and cisplatin in patients with ASS1-deficient non-squamous non-small cell lung cancer
(Wiley, 2021-08-12)Introduction We evaluated the arginine-depleting enzyme pegargiminase (ADI-PEG20; ADI) with pemetrexed (Pem) and cisplatin (Cis) (ADIPemCis) in ASS1-deficient non-squamous non-small cell lung cancer (NSCLC) via a phase 1 ... -
Phase 1b study of pegylated arginine deiminase (ADI-PEG 20) plus Pembrolizumab in advanced solid cancers
(Taylor & Francis, 2021-01-01) -
Mapping Rora expression in resting and activated CD4+ T cells.
(Public Library of Science, 2021-05-18)The transcription factor Rora has been shown to be important for the development of ILC2 and the regulation of ILC3, macrophages and Treg cells. Here we investigate the role of Rora across CD4+ T cells in general, but with ... -
A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division
(2019-07-19)bioRxiv preprint version. Now published in Nature Communications doi: 10.1038/s41467-020-14978-7. -
Long Noncoding RNAs at the Crossroads of Cell Cycle and Genome Integrity
(Elsevier, 2021-03-01) -
The role of CAF derived exosomal microRNAs in the tumour microenvironment of melanoma.
(2020-10-22)Exosomes play a crucial role in the crosstalk between cancer associated fibroblasts (CAFs) and cancer cells, contributing to carcinogenesis and the tumour microenvironment. Recent studies have revealed that CAFs, normal ... -
The Identification of Plasma Exosomal miR-423-3p as a Potential Predictive Biomarker for Prostate Cancer Castration-Resistance Development by Plasma Exosomal miRNA Sequencing
(Frontiers, 2021-01-07)Castration-resistant prostate cancer (CRPC) is the major cause of death from prostate cancer. Biomarkers to improve early detection and prediction of CRPC especially using non-invasive liquid biopsies could improve outcomes. ... -
Extended lifespan of bronchial epithelial cells maintains normal cellular phenotype and transcriptome integrity
(European Respiratory Society, 2021-01-18)