Browsing Centre for Translational Medicine & Therapeutics by Title
Now showing items 369-388 of 842
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The impact of extended bed rest on the musculoskeletal system in the critical care environment.
(2015)Prolonged immobility is harmful with rapid reductions in muscle mass, bone mineral density and impairment in other body systems evident within the first week of bed rest which is further exacerbated in individuals with ... -
The impact of frailty on ICU and 30-day mortality and the level of care in very elderly patients (≥ 80 years).
(Springer Berlin Heidelberg, 2017-09-21)PURPOSE: Very old critical ill patients are a rapid expanding group in the ICU. Indications for admission, triage criteria and level of care are frequently discussed for such patients. However, most relevant outcome studies ... -
Implications for post critical illness trial design: sub-phenotyping trajectories of functional recovery among sepsis survivors.
(2020-09-25)BACKGROUND: Patients who survive critical illness suffer from a significant physical disability. The impact of rehabilitation strategies on health-related quality of life is inconsistent, with population heterogeneity cited ... -
Improving care at scale: process evaluation of a multi-component quality improvement intervention to reduce mortality after emergency abdominal surgery (EPOCH trial).
(2018-11-13)BACKGROUND: Improving the quality and safety of perioperative care is a global priority. The Enhanced Peri-Operative Care for High-risk patients (EPOCH) trial was a stepped-wedge cluster randomised trial of a quality ... -
Incidence of accidental awareness during general anaesthesia in obstetrics: a multicentre, prospective cohort study.
(2021-06)General anaesthesia for obstetric surgery has distinct characteristics that may contribute towards a higher risk of accidental awareness during general anaesthesia. The primary aim of this study was to investigate the ... -
The incidence of myocardial injury following post-operative Goal Directed Therapy.
(2007-03-19)BACKGROUND: Studies suggest that Goal Directed Therapy (GDT) results in improved outcome following major surgery. However, there is concern that pre-emptive use of inotropic therapy may lead to an increased incidence of ...