Browsing Centre for Translational Medicine & Therapeutics by Title
Now showing items 227-246 of 828
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Early elevation in plasma high-sensitivity troponin T and morbidity after elective noncardiac surgery: prospective multicentre observational cohort study.
(2020-03-05)BACKGROUND: Elevated high-sensitivity troponin (hsTnT) after noncardiac surgery is associated with higher mortality, but the temporal relationship between early elevated troponin and the later development of noncardiac ... -
Early Osmotherapy in Severe Traumatic Brain Injury: An International Multicenter Study.
(2020-01-01)The optimal osmotic agent to treat intracranial hypertension in patients with severe traumatic brain injury (TBI) remains uncertain. We aimed to test whether the choice of mannitol or hypertonic saline (HTS) as early (first ... -
Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial.
(2023-04-11)IMPORTANCE: Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. OBJECTIVE: To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin ... -
Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.
(2020-10-06)Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, ... -
Effect of intermittent or continuous feed on muscle wasting in critical illness: A phase II clinical trial.
(Elsevier Inc., 2020-04-02)BACKGROUND: Acute skeletal muscle wasting in critical illness is associated with excess morbidity and mortality. Continuous feeding may suppress muscle protein synthesis as a result of the muscle-full effect, unlike ... -
The effect of intermittent or continuous feeding and amino acid concentration on urea-to-creatinine ratio in critical illness.
(2021-08-31)BACKGROUND: We sought to determine whether peaks in essential amino acid concentration associated with intermittent feeding may provide anabolic advantages when compared to continuous feeding regimens in critical care. ...