• Login
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    The incidence of myocardial injury following post-operative Goal Directed Therapy. 
    •   QMRO Home
    • William Harvey Research Institute
    • Centre for Translational Medicine & Therapeutics
    • The incidence of myocardial injury following post-operative Goal Directed Therapy.
    •   QMRO Home
    • William Harvey Research Institute
    • Centre for Translational Medicine & Therapeutics
    • The incidence of myocardial injury following post-operative Goal Directed Therapy.
    ‌
    ‌

    Browse

    All of QMROCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    ‌
    ‌

    Administrators only

    Login
    ‌
    ‌

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    The incidence of myocardial injury following post-operative Goal Directed Therapy.

    View/Open
    The incidence of myocardial injury following post-operative Goal Directed Therapy..pdf (469.4Kb)
    Volume
    7
    Pagination
    10 - ?
    DOI
    10.1186/1471-2261-7-10
    Journal
    BMC Cardiovasc Disord
    Metadata
    Show full item record
    Abstract
    BACKGROUND: Studies suggest that Goal Directed Therapy (GDT) results in improved outcome following major surgery. However, there is concern that pre-emptive use of inotropic therapy may lead to an increased incidence of myocardial ischaemia and infarction. METHODS: Post hoc analysis of data collected prospectively during a randomised controlled trial of the effects of post-operative GDT in high-risk general surgical patients. Serum troponin T concentrations were measured at baseline and on day 1 and day 2 following surgery. Continuous ECG monitoring was performed during the eight hour intervention period. Patients were followed up for predefined cardiac complications. A univariate analysis was performed to identify any associations between potential risk factors for myocardial injury and elevated troponin T concentrations. RESULTS: GDT was associated with fewer complications, and a reduced duration of hospital stay. Troponin T concentrations above 0.01 microg l-1 were identified in eight patients in the GDT group and six in the control group. Values increased above 0.05 microg l-1 in four patients in the GDT group and two patients in the control group. There were no overall differences in the incidence of elevated troponin T concentrations. The incidence of cardiovascular complications was also similar. None of the patients, in whom troponin T concentrations were elevated, developed ECG changes indicating myocardial ischaemia during the intervention period. The only factor to be associated with elevated troponin T concentrations following surgery was end-stage renal failure. CONCLUSION: The use of post-operative GDT does not result in an increased incidence of myocardial injury.
    Authors
    Pearse, RM; Dawson, D; Fawcett, J; Rhodes, A; Grounds, RM; Bennett, D
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/9990
    Collections
    • Centre for Translational Medicine & Therapeutics [763]
    Language
    eng
    Copyright statements
    © Pearse et al. 2007
    Twitter iconFollow QMUL on Twitter
    Twitter iconFollow QM Research
    Online on twitter
    Facebook iconLike us on Facebook
    • Site Map
    • Privacy and cookies
    • Disclaimer
    • Accessibility
    • Contacts
    • Intranet
    • Current students

    Modern Slavery Statement

    Queen Mary University of London
    Mile End Road
    London E1 4NS
    Tel: +44 (0)20 7882 5555

    © Queen Mary University of London.