Browsing Centre for Microvascular Research (CMR) by Title
Now showing items 62-81 of 101
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Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post ischemia/reperfusion injury.
(Wiley, 2019-01-11)Ischemia/reperfusion (I/R) injury is a severe inflammatory insult associated with numerous pathologies such as myocardial infarction, stroke and acute kidney injury. I/R injury is characterized by a rapid influx of activated ... -
Neutrophil trafficking to lymphoid tissues: physiological and pathological implications.
(2018-12-25)Recent advances have provided evidence for the involvement of neutrophils in both innate and adaptive immunity, robustly challenging the old dogma that neutrophils are short-lived prototypical innate immune cells solely ... -
Non-invasive strategies for stimulating endogenous repair and regenerative mechanisms in the damaged heart
(Elsevier, 2018-01-01)The adult myocardium, including human, harbours a population of resident multi-potent cardiac stem cells (CSCs), which when stimulated under the right conditions can give rise to new cardiomyocytes and vasculature. Elucidation ... -
A novel role for syndecan-3 in angiogenesis.
(2013)Syndecan-3 is one of the four members of the syndecan family of heparan sulphate proteoglycans and has been shown to interact with numerous growth factors via its heparan sulphate chains. The extracellular core proteins ... -
On-site fabrication of Bi-layered adhesive mesenchymal stromal cell-dressings for the treatment of heart failure.
(2019-07)Mesenchymal stromal/stem cell (MSC)-based therapy is a promising approach for the treatment of heart failure. However, current MSC-delivery methods result in poor donor cell engraftment, limiting the therapeutic efficacy. ... -
Pathological Angiogenesis Requires Syndecan-4 for Efficient VEGFA-Induced VE-Cadherin Internalization
(American Heart Association, 2021-02-18)Objective: VEGFA (Vascular endothelial growth factor A) and its receptor VEGFR2 (vascular endothelial growth factor receptor 2) drive angiogenesis in several pathologies, including diabetic retinopathy, wet age-related ... -
Reparative Macrophage Transplantation for Myocardial Repair: A Refinement of Bone Marrow Mononuclear Cell-Based Therapy
(2019-08-02)Meeting Abstract: 718 from 14th Annual American-Heart-Association's Basic Cardiovascular Sciences (BCVS) Scientific Sessions , Boston, MA. JUL 29-AUG 01, 2019