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    A novel role for syndecan-3 in angiogenesis. 
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    • A novel role for syndecan-3 in angiogenesis.
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    A novel role for syndecan-3 in angiogenesis.

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    Published version (1.967Mb)
    Volume
    2
    Pagination
    270 - ?
    DOI
    10.12688/f1000research.2-270.v1
    Journal
    F1000Res
    ISSN
    2046-1402
    Metadata
    Show full item record
    Abstract
    Syndecan-3 is one of the four members of the syndecan family of heparan sulphate proteoglycans and has been shown to interact with numerous growth factors via its heparan sulphate chains. The extracellular core proteins of syndecan-1,-2 and -4 all possess adhesion regulatory motifs and we hypothesized that syndecan-3 may also possess such characteristics. Here we show that a bacterially expressed GST fusion protein consisting of the entire mature syndecan-3 ectodomain has anti-angiogenic properties and acts via modulating endothelial cell migration. This work identifies syndecan-3 as a possible therapeutic target for anti-angiogenic therapy.
    Authors
    De Rossi, G; Whiteford, JR
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/14730
    Collections
    • Centre for Microvascular Research (CMR) [93]
    Language
    eng
    Copyright statements
    © 2013 De Rossi G and Whiteford JR. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Data associated with the article are available under the terms of the Creative Commons Zero "No rights reserved" data waiver (CC0 1.0 Public domain dedication).
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