Browsing Centre for Microvascular Research (CMR) by Title
Now showing items 21-40 of 100
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A degradatory fate for CCR4 suggests a primary role in Th2 inflammation.
(2020-03)CCR4 is the sole receptor for the chemokines CCL22 and CCL17. Clinical studies of asthmatic airways have shown levels of both ligands and CCR4+ Th2 cells to be elevated, suggestive of a role in disease. Consequently, CCR4 ... -
Design of an Activity-Based Probe for Human Neutrophil Elastase: Implementation of the Lossen Rearrangement To Induce Förster Resonance Energy Transfers.
(2018-02-06)Human neutrophil elastase is an important regulator of the immune response and plays a role in host defense mechanisms and further physiological processes. The uncontrolled activity of this serine protease may cause severe ... -
Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome
(Nature Research, 2019-02-18)CRISPR/Cas9-based therapies hold considerable promise for the treatment of genetic diseases. Among these, Hutchinson–Gilford progeria syndrome, caused by a point mutation in the LMNA gene, stands out as a potential candidate. ... -
The dimeric form of CXCL12 binds to atypical chemokine receptor 1
(American Association for the Advancement of Science (AAAS), 2021-08-17)The pleiotropic chemokine CXCL12 is involved in diverse physiological and pathophysiological processes, including embryogenesis, hematopoiesis, leukocyte migration, and tumor metastasis. It is known to engage the classical ... -
Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis.
(2018-12-18)Neutrophils require directional cues to navigate through the complex structure of venular walls and into inflamed tissues. Here we applied confocal intravital microscopy to analyze neutrophil emigration in cytokine-stimulated ... -
Dynamic trafficking and turnover of JAM-C is essential for endothelial cell migration
(Public Library of Science, 2019-12-02)Junctional complexes between endothelial cells form a dynamic barrier that hinders passive diffusion of blood constituents into interstitial tissues. Remodelling of junctions is an essential process during leukocyte ... -
Evaluation of a novel non-destructive catch and release technology for harvesting autologous adult stem cells.
(Public Library of Science, 2013-01-22)BACKGROUND: Cell based therapies are required now to meet the critical care needs of paediatrics and healthy ageing in an increasingly long-lived human population. Repair of compromised tissue by supporting autologous ... -
The evolving role of preprints in the dissemination of COVID-19 research and their impact on the science communication landscape
(Public Library of Science, 2021-04)The world continues to face a life-threatening viral pandemic. The virus underlying the Coronavirus Disease 2019 (COVID-19), Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has caused over 98 million confirmed ... -
A feeder-free, human plasma-derived hydrogel for maintenance of a human embryonic stem cell phenotype in vitro.
(BioMed Central Ltd., 2012-08-08)BACKGROUND: Human embryonic stem cells (hESCs) represent a tremendous resource for cell therapies and the study of human development; however to maintain their undifferentiated state in vitro they routinely require the use ...