Centre for Biochemical Pharmacology: Recent submissions
Now showing items 161-180 of 333
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International severe asthma registry (ISAR): protocol for a global registry
(BioMed Central, 2020-08-14) -
Treatment With a Marine Oil Supplement Alters Lipid Mediators and Leukocyte Phenotype in Healthy Patients and Those With Peripheral Artery Disease
(Wiley Blackwell on behalf of the American Heart Association, Inc, 2020-07-22) -
The effects of oral corticosteroids on lung function, type-2 biomarkers and patient-reported outcomes in stable asthma: A systematic review and meta-analysis.
(2020-09-14)BACKGROUND: Several studies have investigated the physiological effect of OCS in stable asthma, however these have included heterogeneous populations and outcomes. This paper is the first to combine their results. METHODS: ... -
Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages.
(2017-10-05)Clearance of apoptotic cells (ACs) by phagocytes (efferocytosis) prevents post-apoptotic necrosis and dampens inflammation. Defective efferocytosis drives important diseases, including atherosclerosis. For efficient ... -
Mechanism of succinate efflux upon reperfusion of the ischemic heart.
(2020-08-07)AIMS: Succinate accumulates several-fold in the ischemic heart and is then rapidly oxidised upon reperfusion, contributing to reactive oxygen species (ROS) production by mitochondria. In addition, a significant amount of ... -
Towards precision disease-modelling in experimental myocarditis.
(OUP, 2020-03-13) -
Intracellular sodium elevation reprograms cardiac metabolism.
(2020-08-28)Intracellular Na elevation in the heart is a hallmark of pathologies where both acute and chronic metabolic remodelling occurs. Here, we assess whether acute (75 μM ouabain 100 nM blebbistatin) or chronic myocardial Nai ... -
Enzymatic studies with 3-oxa n-3 DPA.
(Elsevier, 2020-02-08)Cyclooxygenase-2 and several lipoxygenases convert polyunsaturated fatty acids into a large variety of products. During inflammatory processes, these enzymes form several distinct families of specialized pro-resolving lipid ... -
Toward gene therapy in rheumatoid arthritis
(Informa UK Limited, 2020)Introduction: Rheumatoid arthritis (RA) is an autoimmune disease of the joint, affecting 0.24% of the global population. Many patients only respond partially or not at all to current therapies while the systemic complications ... -
Magnetically responsive layer-by-layer microcapsules can be retained in cells and under flow conditions to promote local drug release without triggering ROS production.
(Royal Society of Chemistry, 2020-03-25)Nanoengineered vehicles have the potential to deliver cargo drugs directly to disease sites, but can potentially be cleared by immune system cells or lymphatic drainage. In this study we explore the use of magnetism to ... -
A pro-resolving role for Galectin-1 in acute inflammation
(Frontiers Media, 2020-03-20)Galectin-1 (Gal-1) exerts immune-regulatory and anti-inflammatory actions in animal models of acute and chronic inflammation. Its release into the extracellular milieu often correlates with the peak of inflammation suggesting ...