Browsing Centre for Biochemical Pharmacology by Author "Walker, ME"
Now showing items 1-10 of 10
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13-Series resolvins mediate the leukocyte-platelet actions of atorvastatin and pravastatin in inflammatory arthritis
Walker, ME; Souza, PR; Colas, RA; Dalli, J (2017-08) -
ERV1/ChemR23 Signaling Protects Against Atherosclerosis by Modifying Oxidized Low-Density Lipoprotein Uptake and Phagocytosis in Macrophages.
Laguna-Fernandez, A; Checa, A; Carracedo, M; Artiach, G; Petri, MH; Baumgartner, R; Forteza, MJ; Jiang, X; Andonova, T; Walker, ME (2018-10-16)BACKGROUND: In addition to enhanced proinflammatory signaling, impaired resolution of vascular inflammation plays a key role in atherosclerosis. Proresolving lipid mediators formed through the 12/15 lipoxygenase pathways ... -
The GPR40 Agonist GW9508 Enhances Neutrophil Function to Aid Bacterial Clearance DuringE. coliInfections
Souza, PR; Walker, ME; Goulding, NJ; Dalli, J; Perretti, M; Norling, LV (2020-09-29) -
Impaired Production and Diurnal Regulation of Vascular RvDn-3 DPA Increase Systemic Inflammation and Cardiovascular Disease.
Colas, RA; Souza, PR; Walker, ME; Burton, M; Zasłona, Z; Curtis, AM; Marques, RM; Dalli, J (2018-03-16)RATIONALE: Diurnal mechanisms are central to regulating host responses. Recent studies uncovered a novel family of mediators termed as specialized proresolving mediators that terminate inflammation without interfering with ... -
Leukocytes from obese individuals exhibit an impaired SPM signature.
López-Vicario, C; Titos, E; Walker, ME; Alcaraz-Quiles, J; Casulleras, M; Durán-Güell, M; Flores-Costa, R; Pérez-Romero, N; Forné, M; Dalli, J (2019-06)Specialized proresolving mediators (SPMs) biosynthesized from docosahexaenoic acids (DHAs) including resolvins (Rvs), protectins, and maresins are potent endogenous autacoids that actively resolve inflammation, protect ... -
Lipid Mediator Metabolomics Via LC-MS/MS Profiling and Analysis.
Dalli, J; Colas, RA; Walker, ME; Serhan, CN (2018)Solid-phase extraction coupled with liquid chromatography tandem mass spectrometry provides a robust and sensitive approach for the identification and quantitation of specialized pro-resolving mediators (lipoxins, resolvins, ... -
Loss of 15-lipoxygenase disrupts T-reg differentiation altering their pro-resolving functions
Marques, RM; Gonzalez-Nunez, M; Walker, ME; Gomez, EA; Colas, RA; Montero-Melendez, T; Perretti, M; Dalli, J (2021-05-27) -
Novel n-3 Docosapentaneoic Acid-Derived Pro-resolving Mediators Are Vasculoprotective and Mediate the Actions of Statins in Controlling Inflammation
Dalli, J; Pistorius, K; Walker, ME (2019) -
Protective activities of distinct omega-3 enriched oils are linked to their ability to upregulate specialized pro-resolving mediators.
Sobrino, A; Walker, ME; Colas, RA; Dalli, J (Public Library of Science, 2020)Clinical studies using a range of omega-3 supplements have yielded conflicting results on their efficacy to control inflammation. Omega-3 fatty acids are substrate for the formation of potent immune-protective mediators, ... -
Synthesis of 13 (R)-Hyd roxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins
Primdahl, KG; Aursnes, M; Walker, ME; Colas, RA; Serhan, CN; Dalli, J; Hansen, TV; Vik, A (2016-10)