Browsing Centre for Biochemical Pharmacology by Author "Serhan, CN"
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Author Correction: A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae.
Ramirez, JL; de Almeida Oliveira, G; Calvo, E; Dalli, J; Colas, RA; Serhan, CN; Ribeiro, JM; Barillas-Mury, C (2023-07-18) -
Human Sepsis Eicosanoid and Proresolving Lipid Mediator Temporal Profiles: Correlations With Survival and Clinical Outcomes.
Dalli, J; Colas, RA; Quintana, C; Barragan-Bradford, D; Hurwitz, S; Levy, BD; Choi, AM; Serhan, CN; Baron, RM (2017-01)OBJECTIVE: To identify and measure recently described chemical mediators, termed specialized pro-resolving mediators that actively regulate the resolution of acute-inflammation, and correlate measurements with clinical ... -
Identification and Actions of the Maresin 1 Metabolome in Infectious Inflammation
Colas, RA; Dalli, J; Chiang, N; Vlasakov, I; Sanger, JM; Riley, IR; Serhan, CN (2016-12-01) -
Identification and structure elucidation of the pro-resolving mediators provides novel leads for resolution pharmacology
Dalli, J; Serhan, CN (2019) -
Immunoresolvents signaling molecules at intersection between the brain and immune system.
Dalli, J; Serhan, CN (2018-02)Understanding mechanisms that control immunity is central in the quest to gain insights into the etiopathology of many of the diseases that afflict modern societies. New results implicate the nervous system as a central ... -
Lipid Mediator Metabolomics Via LC-MS/MS Profiling and Analysis.
Dalli, J; Colas, RA; Walker, ME; Serhan, CN (2018)Solid-phase extraction coupled with liquid chromatography tandem mass spectrometry provides a robust and sensitive approach for the identification and quantitation of specialized pro-resolving mediators (lipoxins, resolvins, ... -
Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages
Dalli, J; Vlasakov, I; Riley, IR; Rodriguez, AR; Spur, BW; Petasis, NA; Chiang, N; Serhan, CN (2016-10-25) -
The novel lipid mediator PD1n-3 DPA: An overview of the structural elucidation, synthesis, biosynthesis and bioactions.
Hansen, TV; Dalli, J; Serhan, CN (2017-11)Resolvins, protectins and maresins are individual families of specialized pro-resolving mediators biosynthesized from the dietary n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid. These ... -
Pro-Resolving Mediators in Regulating and Conferring Macrophage Function.
Dalli, J; Serhan, CN (2017)Macrophages are central in coordinating the host response to both sterile and infective insults. Clearance of apoptotic cells and cellular debris is a key biological action preformed by macrophages that paves the way to ... -
Pro-resolving mediators promote resolution in a human skin model of UV-killed Escherichia coli-driven acute inflammation.
Motwani, MP; Colas, RA; George, MJ; Flint, JD; Dalli, J; Richard-Loendt, A; De Maeyer, RP; Serhan, CN; Gilroy, DW (2018-03-22)While the treatment of inflammatory disorders is generally based on inhibiting factors that drive onset of inflammation, these therapies can compromise healing (NSAIDs) or dampen immunity against infections (biologics). ... -
Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis.
Norling, LV; Headland, SE; Dalli, J; Arnardottir, HH; Haworth, O; Jones, HR; Irimia, D; Serhan, CN; Perretti, M (2016-04-21)Rheumatoid arthritis (RA) is a debilitating disease characterized by persistent accumulation of leukocytes within the articular cavity and synovial tissue. Metabololipidomic profiling of arthritic joints from omega-3 ... -
Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis.
Norling, LV; Headland, SE; Dalli, J; Arnardottir, HH; Haworth, O; Jones, HR; Irimia, D; Serhan, CN; Perretti, M (2023-02-08) -
Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses.
Chiurchiù, V; Leuti, A; Dalli, J; Jacobsson, A; Battistini, L; Maccarrone, M; Serhan, CN (2016-08-24)Resolution of inflammation is a finely regulated process mediated by specialized proresolving lipid mediators (SPMs), including docosahexaenoic acid (DHA)-derived resolvins and maresins. The immunomodulatory role of SPMs ... -
Protectin D1(n-3 DPA) and resolvin D5(n-3 DPA) are effectors of intestinal protection
Gobbetti, T; Dalli, J; Colas, RA; Canova, DF; Aursnes, M; Bonnet, D; Alric, L; Vergnolle, N; Deraison, C; Hansen, TV (2017-04-11) -
Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis
Spite, M; Norling, LV; Summers, L; Yang, R; Cooper, D; Petasis, NA; Flower, RJ; Perretti, M; Serhan, CN (2009-10-29) -
Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation
Arnardottir, HH; Dalli, J; Norling, LV; Colas, RA; Perretti, M; Serhan, CN (2016-09-15) -
Resolving Inflammation: Synthesis, Configurational Assignment, and Biological Evaluations of RvD1n-3 DPA.
Tungen, JE; Gerstmann, L; Vik, A; De Matteis, R; Colas, RA; Dalli, J; Chiang, N; Serhan, CN; Kalesse, M; Hansen, TV (2018-12-04)New drugs that can resolve inflammation without immunosuppressive effects are at the medicinal chemistry frontier. Pro-resolving endogenously formed small molecules, that is, the resolvins, are excellent candidates displaying ... -
Resolvins suppress tumor growth and enhance cancer therapy
Sulciner, ML; Serhan, CN; Gilligan, MM; Mudge, DK; Chang, J; Gartung, A; Lehner, KA; Bielenberg, DR; Schmidt, B; Dalli, J (2018-01) -
Stereoselective synthesis of MaR2(n-3) (DPA)
Sonderskov, J; Tungen, JE; Palmas, F; Dalli, J; Serhan, CN; Stenstrom, Y; Hansen, TV (2020-02-13) -
Synthesis of 13 (R)-Hyd roxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins
Primdahl, KG; Aursnes, M; Walker, ME; Colas, RA; Serhan, CN; Dalli, J; Hansen, TV; Vik, A (2016-10)