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    Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis. 
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    • Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis.
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    Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis.

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    Accepted version (14.16Mb)
    Volume
    1
    Pagination
    e85922 - ?
    DOI
    10.1172/jci.insight.85922
    Journal
    JCI Insight
    Issue
    5
    ISSN
    2379-3708
    Metadata
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    Abstract
    Rheumatoid arthritis (RA) is a debilitating disease characterized by persistent accumulation of leukocytes within the articular cavity and synovial tissue. Metabololipidomic profiling of arthritic joints from omega-3 supplemented mice identified elevated levels of specialized proresolving lipid mediators (SPM) including resolvin D1 (RvD1). Profiling of human RA synovial fluid revealed physiological levels of RvD1, which - once applied to human neutrophils - attenuated chemotaxis. These results prompted analyses of the antiarthritic properties of RvD1 in a model of murine inflammatory arthritis. The stable epimer 17R-RvD1 (100 ng/day) significantly attenuated arthritis severity, cachexia, hind-paw edema, and paw leukocyte infiltration and shortened the remission interval. Metabololipidomic profiling in arthritic joints revealed 17R-RvD1 significantly reduced PGE2 biosynthesis, while increasing levels of protective SPM. Molecular analyses indicated that 17R-RvD1 enhanced expression of genes associated with cartilage matrix synthesis, and direct intraarticular treatment induced chondroprotection. Joint protective actions of 17R-RvD1 were abolished in RvD1 receptor-deficient mice termed ALX/fpr2/3-/- . These investigations open new therapeutic avenues for inflammatory joint diseases, providing mechanistic substance for the benefits of omega-3 supplementation in RA.
    Authors
    Norling, LV; Headland, SE; Dalli, J; Arnardottir, HH; Haworth, O; Jones, HR; Irimia, D; Serhan, CN; Perretti, M
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/12017
    Collections
    • Centre for Biochemical Pharmacology [305]
    Language
    eng
    Licence information
    CC-BY
    Copyright statements
    © 2016 Norling et al.
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