Browsing Centre for Experimental Medicine and Rheumatology (EMR) by Author "Lucchesi, D"
Now showing items 1-20 of 27
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B CELL SYNOVITIS AND CLINICAL PHENOTYPES IN RHEUMATOID ARTHRITIS AT DIFFERENT DISEASE STAGES
Rivellese, F; Humby, F; Bugatti, S; Fossati-Jimack, L; Rizvi, H; Lucchesi, D; Ribera, GL; Nerviani, A; Hands, R; Giorli, G (2019-06) -
B Cell Synovitis and Clinical Phenotypes in Rheumatoid Arthritis: Relationship to Disease Stages and Drug Exposure.
Rivellese, F; Humby, F; Bugatti, S; Fossati-Jimack, L; Rizvi, H; Lucchesi, D; Lliso-Ribera, G; Nerviani, A; Hands, RE; Giorli, G (2019-11-29)OBJECTIVE: To define the relationship of synovial B cells to clinical phenotypes at different stages of disease evolution and drug exposure in rheumatoid arthritis (RA). METHODS: Synovial biopsy specimens and demographic ... -
B CELL-RICH SYNOVITIS IN EARLY AND ESTABLISHED RHEUMATOID ARTHRITIS
Rivellese, F; Humby, F; Bugatti, S; Fossati-Jimack, L; Rizvi, H; Lucchesi, D; Lliso-Ribera, G; Nerviani, A; Hands, R; Giorli, G (2020-04)Meeting abstract P233 from British Society for Rheumatology Annual Conference 2020 -
A clinical and histopathological analysis of the anti-centromere antibody positive subset of primary Sjogren's syndrome
Notarstefano, C; Croia, C; Pontarini, E; Lucchesi, D; Sutcliffe, N; Tappuni, A; Donati, V; Pitzalis, C; Baldini, C; Bombardieri, M (2018) -
A clinical and histopathological analysis of the anti-centromere antibody positive subset of primary Sjögren's syndrome.
Notarstefano, C; Croia, C; Pontarini, E; Lucchesi, D; Sutcliffe, N; Tappuni, A; Donati, V; Pitzalis, C; Baldini, C; Bombardieri, M (2018-05)OBJECTIVES: ACA-positive/primary Sjögren's syndrome (pSS) represents a distinct overlapping entity with intermediate features in between limited systemic sclerosis (lSSc) and pSS. Few data are available on their general ... -
CLINICAL RESPONSE TO RITUXIMAB IS ASSOCIATED WITH PREVENTION OF B-CELL DRIVEN SALIVARY GLAND INFLAMMATION AND EPITHELIAL RESTORATION AS REVEALED BY MOLECULAR PATHOLOGY: RESULTS FROM THE TRACTISS TRIAL IN PRIMARY SJOGREN'S SYNDROME
Pontarini, E; Chowdhury, F; Sciacca, E; Grigoriadou, S; Murray-Brown, W; Rivellese, F; Lucchesi, D; Goldmann, K; Fossati-Jimack, L; Jaworska, E (2022) -
Current views on the pathogenesis of Sjögren's syndrome.
Pontarini, E; Lucchesi, D; Bombardieri, M (Wolters Kluwer Health, Inc., 2018-03)PURPOSE OF REVIEW: The purpose of this review is to provide an insight into the pathophysiological mechanisms involved in the pathogenesis of primary Sjögren's Syndrome (pSS), highlighting recent findings with potential ... -
DENDRITIC CELL-DERIVED IL-27 REGULATES THE MAGNITUDE OF INDUCIBLE ECTOPIC GERMINAL CENTRES BUT FAILS TO DOWNMODULATE IL-17 PRODUCTION IN CD4 T CELLS FROM PATIENTS WITH SJOGREN'S SYNDROME
Lucchesi, D; Coleby, R; Pontarini, E; Prediletto, E; Hill, D; Soria, AD; Rivellese, F; Pitzalis, C; Jones, S; Jones, G (2019-06) -
ENRICHMENT OF T FOLLICULAR-HELPER CELLS (TFH) AND EXCLUSION OF T FOLLICULAR-REGULATORY CELLS (TFR) FROM ECTOPIC GERMINAL CENTERS IN SALIVARY GLANDS OF SJOGREN'S SYNDROME PATIENTS
Pontarini, E; Murray-Brown, W; Croia, C; Astorri, E; Lucchesi, D; Lepse, N; Sutcliffe, N; Tappuni, A; Pitzalis, C; Bombardieri, M (2017) -
The glucose transporter 2 regulates CD8+ T cell function via environment sensing.
Fu, H; Vuononvirta, J; Fanti, S; Bonacina, F; D'Amati, A; Wang, G; Poobalasingam, T; Fankhaenel, M; Lucchesi, D; Coleby, R (2023-11)T cell activation is associated with a profound and rapid metabolic response to meet increased energy demands for cell division, differentiation and development of effector function. Glucose uptake and engagement of the ... -
IL-27 REGULATES THE MAGNITUDE OF ECTOPIC GERMINAL CENTRES IN EXPERIMENTAL SIALADENITIS BUT FAILS TO MODULATE IL-17 AND IFNG PRODUCTION IN CD4 T CELLS FROM PATIENTS WITH SJOGREN'S SYNDROME
Lucchesi, D; Coleby, R; Pontarini, E; Prediletto, E; Rivellese, F; Hill, D; Soria, AD; Jones, S; Humphreys, I; Sutcliffe, N (2020-04) -
Immunofibroblasts regulate LTα3 expression in tertiary lymphoid structures in a pathway dependent on ICOS/ICOSL interaction
Nayar, S; Pontarini, E; Campos, J; Berardicurti, O; Smith, CG; Asam, S; Gardner, DH; Colafrancesco, S; Lucchesi, D; Coleby, R (2022) -
Impaired IL‐27 Mediated Control of CD4+ T Cell Function Impacts on Ectopic Lymphoid Structure Formation in Patients with Sjögren's Syndrome
Lucchesi, D; Coleby, R; Pontarini, E; Prediletto, E; Rivellese, F; Hill, DG; Derrac Soria, A; Jones, SA; Humphreys, IR; Sutcliffe, N (Wiley, 2020-04-20)This is the pre-peer reviewed version of the following article: Lucchesi, D., Coleby, R., Pontarini, E., Prediletto, E., Rivellese, F., Hill, D.G., Derrac Soria, A., Jones, S.A., Humphreys, I.R., Sutcliffe, N., Tappuni, ... -
Interleukin-36 family dysregulation drives joint inflammation and therapy response in psoriatic arthritis.
Boutet, M-A; Nerviani, A; Lliso-Ribera, G; Lucchesi, D; Prediletto, E; Ghirardi, GM; Goldmann, K; Lewis, M; Pitzalis, C (2020-04-01)OBJECTIVES: IL-36 agonists are pro-inflammatory cytokines involved in the pathogenesis of psoriasis. However, their role in the pathogenesis of arthritis and treatment response to DMARDs in PsA remains uncertain. Therefore, ... -
NK cell recruitment in salivary glands provides early viral control but is dispensable for tertiary lymphoid structure formation.
Pontarini, E; Lucchesi, D; Fossati-Jimack, L; Coleby, R; Tentorio, P; Croia, C; Bombardieri, M; Mavilio, D (2019-11-21)Salivary glands (SGs) represent a permissive site for several sialotropic viruses whose persistence is linked to the development of autoimmunity. Natural Killer (NK) cells play a key role in viral clearance but their ... -
O31 IL-27 regulates the magnitude of ectopic germinal centres in experimental sialadenitis but fails to modulate IL-17 and IFNg production in CD4 T cells from patients with Sjögren's syndrome
Lucchesi, D; Coleby, R; Pontarini, E; Prediletto, E; Rivellese, F; Hill, D; Soria, AD; Jones, S; Humphreys, I; Sutcliffe, N (2020-04-01) -
One year in review 2020: pathogenesis of primary Sjogren's syndrome
Bombardieri, M; Argyropoulou, OD; Ferro, F; Coleby, R; Pontarini, E; Governato, G; Lucchesi, D; Fulvio, G; Tzioufas, AG; Baldini, C (2020) -
One year in review 2020: pathogenesis of primary Sjögren's syndrome.
Bombardieri, M; Argyropoulou, OD; Ferro, F; Coleby, R; Pontarini, E; Governato, G; Lucchesi, D; Fulvio, G; Tzioufas, AG; Baldini, C (2020)The pathogenesis of primary Sjögren's syndrome (pSS) remains poorly understood. However, important efforts have been made during the last few months. In this review, following the others of this series we will summarise ... -
OP0136 RITUXIMAB PREVENTS THE PROGRESSION OF B-CELL DRIVEN INFLAMMATORY INFILTRATE IN THE MINOR SALIVARY GLANDS OF PRIMARY SJOGREN’S SYNDROME BY DOWNREGULATING IMMUNOLOGICAL PATHWAYS KEY IN ECTOPIC GERMINAL CENTRE ORGANIZATION: RESULTS FROM THE TRACTISS TRIAL
Pontarini, E; Chowdhury, F; Sciacca, E; Grigoriadou, S; Rivellese, F; Lucchesi, D; Goldmann, K; Fossati-Jimack, L; Emery, P; Ng, WF (2021-05-19) -
Rheumatoid Synovial Fibroblasts Display Imprinted Memory of Their Synovial Endotype Which Can Be Plastically Modulated by B-cells Crosstalk
Prediletto, E; Cubuk, C; Pontarini, E; Rivellese, F; Nerviani, A; Lucchesi, D; Caliste, M; Corsiero, E; Ahmed, M; Hands, R (2022)