Browsing Centre for Experimental Medicine and Rheumatology (EMR) by Author "Kelly, S"
Now showing items 1-20 of 26
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Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early Rheumatoid Arthritis: an observational study.
Kelly, S; Bombardieri, M; Humby, F; Ng, N; Marrelli, A; Riahi, S; DiCicco, M; Mahto, A; Zou, L; Pyne, D (2015-03-13)INTRODUCTION: Neovascularization contributes to the development of sustained synovial inflammation in the early stages of Rheumatoid Arthritis. Ultrasound (US) provides an indirect method of assessing synovial blood flow ... -
DEFINING A LEARNING CURVE FOR CLINICIANS PERFORMING ULTRASOUND-GUIDED DEFINING A LEARNING CURVE FOR CLINICIANS PERFORMING ULTRASOUND-GUIDED NEEDLE SYNOVIAL BIOPSIES: A RETROSPECTIVE ANALYSIS OF THE EXPERIENCE AT THE EXPERIMENTAL MEDICINE AND RHEUMATOLOGY, QUEEN MARY UNIVERSITY OF LONDON
Nerviani, A; Humby, F; Ribera, GL; Rivellese, F; Kelly, S; Hands, R; Pitzalis, C (2019-06) -
Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium
Humby, F; Bombardieri, M; Manzo, A; Kelly, S; Blades, MC; Kirkham, B; Spencer, J; Pitzalis, C (2009-01) -
Efficacy, Safety, and Sample Quality of Ultrasound-Guided Synovial Needle Biopsy in Clinical Practice and Research: A Prospective Observational Study
Romao, VC; Polido-Pereira, J; Barros, R; Luis, R; Vidal, B; Vieira-Sousa, E; Vitorino, E; Humby, F; Kelly, S; Pitzalis, C (2020-10) -
Evaluation of Minimally Invasive, Ultrasound-guided Synovial Biopsy Techniques by the OMERACT Filter - Determining Validation Requirements
Humby, F; Kelly, S; Bugatti, S; Manzo, A; Filer, A; Mahto, A; Fonseca, JE; Lauwerys, B; D'Agostino, M-A; Naredo, E (2016-01) -
HISTOLOGICAL AND MOLECULAR FEATURES OF THE DISEASED SYNOVIUM IN EARLY UNTREATED PSA IN COMPARISON WITH RA
Nerviani, A; Lliso-Ribera, G; Boutet, M-A; Goldmann, K; Rivellese, F; Kelly, S; Bombardieri, M; Lewis, M; Humby, F; Pitzalis, C (2020-04) -
IL-23 skin and joint profiling in Psoriatic Arthritis: novel perspectives in understanding clinical responses to IL-23 inhibitors
Nerviani, A; Boutet, M-A; Tan, WSG; Goldmann, K; Purkayastha, N; Lajtos, T; Hands, R; Lewis, M; Kelly, S; Pitzalis, C -
Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes
Lewis, MJ; Barnes, MR; Blighe, K; Goldmann, K; Rana, S; Hackney, JA; Ramamoorthi, N; John, CR; Watson, DS; Kummerfeld, SK (2019-08-27) -
A Multicenter Retrospective Analysis Evaluating Performance of Synovial Biopsy Techniques in Patients With Inflammatory Arthritis Arthroscopic Versus Ultrasound-Guided Versus Blind Needle Biopsy
Humby, F; Romao, VC; Manzo, A; Filer, A; Bugatti, S; Vieira-Sousa, E; Kelly, S; Wechalekar, M; Ahmed, M; Rocher, V (2018-05) -
O07 Randomised, open labelled clinical trial to investigate synovial mechanisms determining response: resistance to rituximab versus tocilizumab in RA patients failing TNF inhibitor therapy
Humby, FC; Lewis, M; Durez, P; Buch, MH; Bombardieri, M; Rizvi, H; Rivellese, F; Fossati, L; Hands, R; Giorli, G (2020-04-01) -
O20 Histological and molecular features of the diseased synovium in early untreated PsA in comparison with RA
Nerviani, A; Lliso-Ribera, G; Boutet, M-A; Goldmann, K; Rivellese, F; Kelly, S; Bombardieri, M; Lewis, M; Humby, F; Pitzalis, C (2020-04-01) -
A Pauci-Immune Synovial Pathotype Predicts Inadequate Response to TNF alpha-Blockade in Rheumatoid Arthritis Patients
Nerviani, A; Di Cicco, M; Mahto, A; Lliso-Ribera, G; Rivellese, F; Thorborn, G; Hands, R; Bellan, M; Mauro, D; Boutet, M-A (2020-05-05) -
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients
Isaacs, JD; Brockbank, S; Pedersen, AW; Hilkens, C; Anderson, A; Stocks, P; Lendrem, D; Tarn, J; Smith, GR; Allen, B (2022) -
A Randomised, Open Labelled Clinical Trial to Investigate Synovial Mechanisms Determining Response - Resistance to Rituximab versus Tocilizumab in Rheumatoid Arthritis Patients Failing TNF Inhibitor Therapy
Humby, F; Buch, MH; Durez, P; Lewis, M; Bombardieri, M; Rizvi, H; Kelly, S; Fosatti, L; Hands, R; Giorli, G (2019-10) -
RANDOMISED, OPEN LABELLED CLINICAL TRIAL TO INVESTIGATE SYNOVIAL MECHANISMS DETERMINING RESPONSE: RESISTANCE TO RITUXIMAB VERSUS TOCILIZUMAB IN RA PATIENTS FAILING TNF INHIBITOR THERAPY
Humby, FC; Lewis, M; Durez, P; Buch, MH; Bombardieri, M; Rizvi, H; Rivellese, F; Fossati, L; Hands, R; Giorli, G (2020-04) -
The Relationship Between Synovial Pathobiology and Magnetic Resonance Imaging Abnormalities in Rheumatoid Arthritis: A Systematic Review
Humby, F; Mahto, A; Ahmed, M; Barr, A; Kelly, S; Buch, M; Pitzalis, C; Conaghan, PG (2017-09-01) -
Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial.
Humby, F; Durez, P; Buch, MH; Lewis, MJ; Rizvi, H; Rivellese, F; Nerviani, A; Giorli, G; Mahto, A; Montecucco, C (2021-01-23)BACKGROUND: Although targeted biological treatments have transformed the outlook for patients with rheumatoid arthritis, 40% of patients show poor clinical response, which is mechanistically still unexplained. Because more ... -
Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials
Rivellese, F; Nerviani, A; Giorli, G; Warren, L; Jaworska, E; Bombardieri, M; Lewis, MJ; Humby, F; Pratt, AG; Filer, A (2023-11-01)Background: Despite highly effective targeted therapies for rheumatoid arthritis, about 40% of patients respond poorly, and predictive biomarkers for treatment choices are lacking. We did a biopsy-driven trial to compare ... -
Synovial Mast Cells Associate with High Disease Activity and Predict Radiographic Progression at 12 Months in Patients with Early Rheumatoid Arthritis
Rivellese, F; Humby, F; Kelly, S; de Paulis, A; Marone, G; Pitzalis, C (2016) -
SYNOVIAL MAST CELLS CORRELATE WITH INFLAMMATION AND CELLULAR INFILTRATION AND ARE ASSOCIATED WITH ECTOPIC LYMPHOID STRUCTURES IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS
Rivellese, F; Humby, F; Kelly, S; Rocher, V; Pitzalis, C (Oxford University Press, 2016-04-24)The analysis of synovial membrane has gained much attention in recent years as a biomarker for patient stratification in RA. Different degrees of cellular infiltration have been described, leading to the definition of ...