Browsing Centre for Experimental Medicine and Rheumatology (EMR) by Author "Humby, F"
Now showing items 1-20 of 46
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Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early Rheumatoid Arthritis: an observational study.
Kelly, S; Bombardieri, M; Humby, F; Ng, N; Marrelli, A; Riahi, S; DiCicco, M; Mahto, A; Zou, L; Pyne, D (2015-03-13)INTRODUCTION: Neovascularization contributes to the development of sustained synovial inflammation in the early stages of Rheumatoid Arthritis. Ultrasound (US) provides an indirect method of assessing synovial blood flow ... -
Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis.
Nerviani, A; Boutet, M-A; Ghirardi, GM; Goldmann, K; Sciacca, E; Rivellese, F; Pontarini, E; Prediletto, E; Abatecola, F; Caliste, M (2024-03-16)The TAM tyrosine kinases, Axl and MerTK, play an important role in rheumatoid arthritis (RA). Here, using a unique synovial tissue bioresource of patients with RA matched for disease stage and treatment exposure, we assessed ... -
B CELL SYNOVITIS AND CLINICAL PHENOTYPES IN RHEUMATOID ARTHRITIS AT DIFFERENT DISEASE STAGES
Rivellese, F; Humby, F; Bugatti, S; Fossati-Jimack, L; Rizvi, H; Lucchesi, D; Ribera, GL; Nerviani, A; Hands, R; Giorli, G (2019-06) -
B Cell Synovitis and Clinical Phenotypes in Rheumatoid Arthritis: Relationship to Disease Stages and Drug Exposure.
Rivellese, F; Humby, F; Bugatti, S; Fossati-Jimack, L; Rizvi, H; Lucchesi, D; Lliso-Ribera, G; Nerviani, A; Hands, RE; Giorli, G (2019-11-29)OBJECTIVE: To define the relationship of synovial B cells to clinical phenotypes at different stages of disease evolution and drug exposure in rheumatoid arthritis (RA). METHODS: Synovial biopsy specimens and demographic ... -
B CELL-RICH SYNOVITIS IN EARLY AND ESTABLISHED RHEUMATOID ARTHRITIS
Rivellese, F; Humby, F; Bugatti, S; Fossati-Jimack, L; Rizvi, H; Lucchesi, D; Lliso-Ribera, G; Nerviani, A; Hands, R; Giorli, G (2020-04)Meeting abstract P233 from British Society for Rheumatology Annual Conference 2020 -
DEFINING A LEARNING CURVE FOR CLINICIANS PERFORMING ULTRASOUND-GUIDED DEFINING A LEARNING CURVE FOR CLINICIANS PERFORMING ULTRASOUND-GUIDED NEEDLE SYNOVIAL BIOPSIES: A RETROSPECTIVE ANALYSIS OF THE EXPERIENCE AT THE EXPERIMENTAL MEDICINE AND RHEUMATOLOGY, QUEEN MARY UNIVERSITY OF LONDON
Nerviani, A; Humby, F; Ribera, GL; Rivellese, F; Kelly, S; Hands, R; Pitzalis, C (2019-06) -
Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium
Humby, F; Bombardieri, M; Manzo, A; Kelly, S; Blades, MC; Kirkham, B; Spencer, J; Pitzalis, C (2009-01) -
Efficacy, Safety, and Sample Quality of Ultrasound-Guided Synovial Needle Biopsy in Clinical Practice and Research: A Prospective Observational Study
Romao, VC; Polido-Pereira, J; Barros, R; Luis, R; Vidal, B; Vieira-Sousa, E; Vitorino, E; Humby, F; Kelly, S; Pitzalis, C (2020-10) -
Evaluation of Minimally Invasive, Ultrasound-guided Synovial Biopsy Techniques by the OMERACT Filter - Determining Validation Requirements
Humby, F; Kelly, S; Bugatti, S; Manzo, A; Filer, A; Mahto, A; Fonseca, JE; Lauwerys, B; D'Agostino, M-A; Naredo, E (2016-01) -
Higher expression of TNF alpha-induced genes in the synovium of patients with early rheumatoid arthritis correlates with disease activity, and predicts absence of response to first line therapy
De Groof, A; Ducreux, J; Humby, F; Toukap, AN; Badot, V; Pitzalis, C; Houssiau, FA; Durez, P; Lauwerys, BR (2016-01-20) -
Histo-pathological Cellular Markers of Treatment Response to Rituximab and Tocilizumab in Matched Pre- and Post-treatment Synovial Biopsies from the R4RA Randomised Clinical Trial in Rheumatoid Arthritis
Rivellese, F; Humby, F; Giorli, G; Nerviani, A; Hands, R; Fossati-Jimack, L; Thorborn, G; Lewis, M; Pitzalis, C (2020-10) -
HISTOLOGICAL AND MOLECULAR FEATURES OF THE DISEASED SYNOVIUM IN EARLY UNTREATED PSA IN COMPARISON WITH RA
Nerviani, A; Lliso-Ribera, G; Boutet, M-A; Goldmann, K; Rivellese, F; Kelly, S; Bombardieri, M; Lewis, M; Humby, F; Pitzalis, C (2020-04) -
Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression.
Guo, Y; Walsh, AM; Canavan, M; Wechalekar, MD; Cole, S; Yin, X; Scott, B; Loza, M; Orr, C; McGarry, T (Public Library of Science, 2018-02-28)Immune checkpoint blockade with therapeutic anti-cytotoxic T lymphocyte-associated antigen (CTLA)-4 (Ipilimumab) and anti-programmed death (PD)-1 (Nivolumab and Pembrolizumab) antibodies alone or in combination has shown ... -
Inflammatory cytokines shape a changing DNA methylome in monocytes mirroring disease activity in rheumatoid arthritis
Rodriguez-Ubreva, J; de la Calle-Fabregat, C; Li, T; Ciudad, L; Ballestar, ML; Catala-Moll, F; Morante-Palacios, O; Garcia-Gomez, A; Celis, R; Humby, F (BMJ, 2019-11) -
Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus
Cole, S; Walsh, A; Yin, X; Wechalekar, MD; Smith, MD; Proudman, SM; Veale, DJ; Fearon, U; Pitzalis, C; Humby, F (2018-05-02) -
INVOLVEMENT OF LARGE JOINTS AT DISEASE PRESENTATION IS ASSOCIATED WITH DIVERSE HISTOPATHOLOGICAL FEATURES AND CLINICAL OUTCOMES IN EARLY RHEUMATOID ARTHRITIS
Rivellese, F; Humby, F; Ribera, GL; Nerviani, A; Sciacca, E; Giorli, G; Hands, R; Fossati-Jimack, L; Thorborn, G; Lewis, M (BMJ, 2020-06)Abstract OP0217 from Annual European Congress of Rheumatology (EULAR), 2020. -
Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4(+) T Cell Metabolic Rewiring
Pucino, V; Certo, M; Bulusu, V; Cucchi, D; Goldmann, K; Pontarini, E; Haas, R; Smith, J; Headland, SE; Blighe, K (2019-12-03) -
Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production
Rivellese, F; Mauro, D; Nerviani, A; Pagani, S; Fossati-Jimack, L; Messemaker, T; Kurreeman, FAS; Toes, REM; Ramming, A; Rauber, S (2018-12) -
MerTK Synovial Expression Correlates with Disease Activity and Treatment Response in Rheumatoid Arthritis Patients
Nerviani, A; Boutet, M-A; Ghirardi, GM; Lliso-Ribera, G; Rivellese, F; Lewis, M; Bombardieri, M; Humby, F; Pitzalis, C (2020-10) -
MICRO-RNA ENRICHED PATHWAY IMPACT ANALYSIS APPLIED TO SYNOVIAL RNA-SEQ IN EARLY RHEUMATOID ARTHRITIS IDENTIFIES RESPONSE PREDICTION PATHWAYS
Sciacca, E; Alaimo, S; Pulvirenti, A; Latora, V; Humby, F; Ferro, A; Lewis, MJ; Pitzalis, C (2020)