Browsing Centre for Experimental Medicine and Rheumatology (EMR) by Title
Now showing items 250-269 of 470
-
M3C: Monte Carlo reference-based consensus clustering
(bioRxiv, 2019-12-04)Abstract: Genome-wide data is used to stratify patients into classes for precision medicine using clustering algorithms. A common problem in this area is selection of the number of clusters (K). The Monti consensus clustering ... -
M3C: Monte Carlo reference-based consensus clustering.
(2020-02-04)Genome-wide data is used to stratify patients into classes for precision medicine using clustering algorithms. A common problem in this area is selection of the number of clusters (K). The Monti consensus clustering algorithm ... -
Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution.
(2023-12)The human leukocyte antigen (HLA) locus plays a critical role in complex traits spanning autoimmune and infectious diseases, transplantation and cancer. While coding variation in HLA genes has been extensively documented, ... -
Markedly different pathogenicity of four immunoglobulin G isotype-switch variants of an antierythrocyte autoantibody is based on their capacity to interact in vivo with the low-affinity Fcgamma receptor III.
(2000-04-17)Using three different Fcgamma receptor (FcgammaR)-deficient mouse strains, we examined the induction of autoimmune hemolytic anemia by each of the four immunoglobulin (Ig)G isotype-switch variants of a 4C8 IgM antierythrocyte ... -
Mast Cells in Early Rheumatoid Arthritis
(2019-04-02) -
Mechanistic modeling of the SARS-CoV-2 disease map.
(BioMed Central, 2021-01-21)Here we present a web interface that implements a comprehensive mechanistic model of the SARS-CoV-2 disease map. In this framework, the detailed activity of the human signaling circuits related to the viral infection, ... -
Melanocortin peptide therapy for the treatment of arthritic pathologies.
(2009-12-16)Arthritic pathologies are a major cause of morbidity within the western world, with rheumatoid arthritis affecting approximately 1% of adults. This review highlights the therapeutic potential of naturally occurring hormones ... -
MMP-3 in the peripheral serum as a biomarker of knee osteoarthritis, 40 years after open total knee meniscectomy.
(2018-06-15)BACKGROUND: To explore potential biomarkers in a meniscectomy-induced knee osteoarthritis model, at forty years after meniscectomy. METHODS: We carried out a forty-year study of 53 patients who, as adolescents, underwent ... -
Modeling Functional Modules Using Statistical and Machine Learning Methods
(Universitat Politècnica de València, 2020)Understanding the aspects of the cell functionality that account for disease or drug action mechanisms is the main challenge for precision medicine. In spite of the increasing availability of genomic and transcriptomic ...