Browsing Centre for Experimental Medicine and Rheumatology (EMR) by Title
Now showing items 164-183 of 470
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Generation of Recombinant Monoclonal Antibodies from Single B Cells Isolated from Synovial Tissue of Rheumatoid Arthritis Patients.
(Humana Press, 2018-08-24)Ectopic lymphoid structure (ELS) can form in the target tissues of patients with chronic inflammatory autoimmune diseases such as rheumatoid arthritis (RA) and Sjögren's syndrome (SS). Although it is still not clear why ... -
Genetic Factors of the Disease Course after Sepsis: A Genome-Wide Study for 28Day Mortality.
(2016-10)Sepsis is the dysregulated host response to an infection which leads to life-threatening organ dysfunction that varies by host genomic factors. We conducted a genome-wide association study (GWAS) in 740 adult septic patients ... -
The glucose transporter 2 regulates CD8+ T cell function via environment sensing.
(2023-11)T cell activation is associated with a profound and rapid metabolic response to meet increased energy demands for cell division, differentiation and development of effector function. Glucose uptake and engagement of the ... -
GPR101 mediates the pro-resolving actions of RvD5(n-3 DPA)in arthritis and infections
(American Society for Clinical Investigation, 2019-12-03)N-3 docosapentaenoic acid–derived resolvin D5 (RvD5n-3 DPA) is diurnally regulated in peripheral blood and exerts tissue-protective actions during inflammatory arthritis. Here, using an orphan GPCR screening approach coupled ... -
The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts' Consensus.
(2021-02)Autoimmune diseases (AIDs) share similar serological, clinical, and radiological findings, but, behind these common features, there are different pathogenic mechanisms, immune cells dysfunctions, and targeted organs. In ... -
Guidelines for biomarkers in autoimmune rheumatic diseases - evidence based analysis.
(Elsevier B.V., 2019-01)Autoimmune rheumatic diseases are characterised by an abnormal immune system response, complement activation, cytokines dysregulation and inflammation. In last years, despite many progresses in managing these patients, it ... -
Heterogeneity of Human Mast Cells With Respect to MRGPRX2 Receptor Expression and Function.
(Frontiers Media SA, 2019-07-03)Mast cells and their mediators play a role in the control of homeostasis and in the pathogenesis of several disorders. The concept of rodent mast cell heterogeneity, initially established in the mid-1960s has been extended ... -
High pathogenic potential of low-affinity autoantibodies in experimental autoimmune hemolytic anemia.
(1999-12-06)To assess the potency of low-affinity anti-red blood cell (RBC) autoantibodies in the induction of anemia, we generated an immunoglobulin (Ig)G2a class-switch variant of a 4C8 IgM anti-mouse RBC autoantibody, and compared ... -
High volume image guided injections and structured rehabilitation in shoulder impingement syndrome: a retrospective study.
(2015-07)BACKGROUND: the aim was to establish the effect of a high volume-image guided injection and structured rehabilitation (HVIGI&SR) on both pain and function in shoulder impingement syndrome (SIS). METHODS: 44 participants ...