Browsing Centre for Experimental Medicine and Rheumatology (EMR) by Title
Now showing items 40-59 of 470
-
B cell depletion with rituximab in the treatment of primary Sjögren's syndrome: what have we learnt?
(2019-05)Despite the well-established role of B cells in the pathogenesis of primary Sjögren's syndrome (pSS), the beneficial role of B-cell depletion therapy with rituximab remains elusive in this condition, contrary to other ... -
B Cell Synovitis and Clinical Phenotypes in Rheumatoid Arthritis: Relationship to Disease Stages and Drug Exposure.
(2019-11-29)OBJECTIVE: To define the relationship of synovial B cells to clinical phenotypes at different stages of disease evolution and drug exposure in rheumatoid arthritis (RA). METHODS: Synovial biopsy specimens and demographic ... -
B CELL-RICH SYNOVITIS IN EARLY AND ESTABLISHED RHEUMATOID ARTHRITIS
(2020-04)Meeting abstract P233 from British Society for Rheumatology Annual Conference 2020 -
B cells in the formation of Tertiary Lymphoid Organs in autoimmunity, transplantation and tumorigenesis.
(Elsevier, 2019-02-22)TLS develop in target organs of autoimmune diseases, transplantation and cancer. • TLS can function as germinal centres supporting B-cell selection/differentiation. • TLS can be destructive or have beneficial effects ... -
BCP crystals promote chondrocyte hypertrophic differentiation in OA cartilage by sequestering Wnt3a
(BMJ Publishing Group, 2020-05-05)Objective Calcification of cartilage with basic calcium phosphate (BCP) crystals is a common phenomenon during osteoarthritis (OA). It is directly linked to the severity of the disease and known to be associated to ... -
Biomechanical parameters of the golf swing associated with lower back pain: A systematic review.
(2024-03-06)Low back pain (LBP) is the most common injury in golfers of all abilities. The primary aim of this review was to improve understanding of human golf swing biomechanics associated with LBP. A systematic review using the ... -
Blocking T cell co-stimulation in primary Sjögren's syndrome: rationale, clinical efficacy and modulation of peripheral and salivary gland biomarkers.
(2020)There is accumulating evidence that patients with primary Sjögren's syndrome (pSS) display aberrant CD4+ T cell responses, both in the peripheral compartment and in the inflamed salivary glands. CD4+ T cell abnormalities ... -
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity.
(2022-03-03)Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete description of specific immune biomarkers. We present here a comprehensive multi-omic blood atlas for patients with varying COVID-19 ... -
The British Society for Rheumatology guideline for the management of adults with primary Sjogren's Syndrome
(Oxford University Press (OUP), 2017-06-28) -
Can Synovial Pathobiology Integrate with Current Clinical and Imaging Prediction Models to Achieve Personalized Health Care in Rheumatoid Arthritis?
(2017)Although great progress has been made in the past decade toward understanding the pathogenesis of rheumatoid arthritis (RA), clinicians remain some distance from a goal of personalized health care. The capacity to diagnose ...