Browsing Centre for Experimental Medicine and Rheumatology (EMR) by Title
Now showing items 401-420 of 471
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Spectrum: fast density-aware spectral clustering for single and multi-omic data
(Oxford University Press, 2019-09-10)Motivation Clustering patient omic data is integral to developing precision medicine because it allows the identification of disease subtypes. A current major challenge is the integration multi-omic data to identify a ... -
Spectrum: Fast density-aware spectral clustering for single and multi-omic data
(2019-05-13)Abstract Clustering of single or multi-omic data is key to developing personalised medicine and identifying new cell types. We present Spectrum, a fast spectral clustering method for single and multi-omic expression data. ... -
Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials
(2023-11-01)Background: Despite highly effective targeted therapies for rheumatoid arthritis, about 40% of patients respond poorly, and predictive biomarkers for treatment choices are lacking. We did a biopsy-driven trial to compare ... -
Superantigenic Activation of Human Cardiac Mast Cells.
(MDPI, 2019-04-12)B cell superantigens, also called immunoglobulin superantigens, bind to the variable regions of either the heavy or light chain of immunoglobulins mirroring the lymphocyte-activating properties of classical T cell ... -
Symmetric molecules with 1,4-triazole moieties as potent inhibitors of tumour-associated lactate dehydrogenase-A.
(2018-12)A series of symmetric molecules incorporating aryl or pyridyl moieties as central core and 1,4-substituted triazoles as a side bridge was synthesised. The new compounds were investigated as lactate dehydro-genase (LDH, EC ... -
Synovial biopsies for molecular definition of rheumatoid arthritis and treatment response phenotyping: where can we improve?
(2023-11-18)INTRODUCTION: The extensive knowledge gained in the cellular and molecular mechanisms underlying Rheumatoid Arthritis (RA) pathogenesis has led to therapeutic advances. However, up to 10-20% of patients fail to respond to ... -
Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients
(BMJ Publishing Group, 2019-03-16)OBJECTIVES: To unravel the hierarchy of cellular/molecular pathways in the disease tissue of early, treatment-naïve rheumatoid arthritis (RA) patients and determine their relationship with clinical phenotypes and treatment ... -
SYNOVIAL MAST CELLS CORRELATE WITH INFLAMMATION AND CELLULAR INFILTRATION AND ARE ASSOCIATED WITH ECTOPIC LYMPHOID STRUCTURES IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS
(Oxford University Press, 2016-04-24)The analysis of synovial membrane has gained much attention in recent years as a biomarker for patient stratification in RA. Different degrees of cellular infiltration have been described, leading to the definition of ...