Browsing Centre for Experimental Medicine and Rheumatology (EMR) by Title
Now showing items 262-281 of 471
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Mechanistic modeling of the SARS-CoV-2 disease map.
(BioMed Central, 2021-01-21)Here we present a web interface that implements a comprehensive mechanistic model of the SARS-CoV-2 disease map. In this framework, the detailed activity of the human signaling circuits related to the viral infection, ... -
Melanocortin peptide therapy for the treatment of arthritic pathologies.
(2009-12-16)Arthritic pathologies are a major cause of morbidity within the western world, with rheumatoid arthritis affecting approximately 1% of adults. This review highlights the therapeutic potential of naturally occurring hormones ... -
MMP-3 in the peripheral serum as a biomarker of knee osteoarthritis, 40 years after open total knee meniscectomy.
(2018-06-15)BACKGROUND: To explore potential biomarkers in a meniscectomy-induced knee osteoarthritis model, at forty years after meniscectomy. METHODS: We carried out a forty-year study of 53 patients who, as adolescents, underwent ... -
Modeling Functional Modules Using Statistical and Machine Learning Methods
(Universitat Politècnica de València, 2020)Understanding the aspects of the cell functionality that account for disease or drug action mechanisms is the main challenge for precision medicine. In spite of the increasing availability of genomic and transcriptomic ... -
Molecular portrait of chronic joint diseases: Defining endotypes toward personalized medicine.
(2024-01-19)Joint diseases affect hundreds of millions of people worldwide, and their prevalence is constantly increasing. To date, despite recent advances in the development of therapeutic options for most rheumatic conditions, a ... -
A Mouse Model of Acute Cartilage Injury and Repair.
(2023)Chondral defects are common and disabling. The development of pharmacological approaches for cartilage repair requires the availability of in vivo models which are amenable for gain and loss of function and ideally to ... -
Musculoskeletal Injury Profile of Circus Artists: A Systematic Review of the Literature.
(2017-03)BACKGROUND: The circus arts involve a high degree of acrobatic, athletic, and aesthetic ability with extreme physical demands placed on performers. An understanding of the injury profile is required to guide prevention. ... -
nestedcv: an R package for fast implementation of nested cross-validation with embedded feature selection designed for transcriptomics and high-dimensional data.
(2023)MOTIVATION: Although machine learning models are commonly used in medical research, many analyses implement a simple partition into training data and hold-out test data, with cross-validation (CV) for tuning of model ... -
NETosis as Source of Autoantigens in Rheumatoid Arthritis
(2016-11-14) -
Neuromuscular Function of the Knee Joint Following Knee Injuries: Does It Ever Get Back to Normal? A Systematic Review with Meta-Analyses.
(Springer, 2020-11-27)BACKGROUND: Neuromuscular deficits are common following knee injuries and may contribute to early-onset post-traumatic osteoarthritis, likely mediated through quadriceps dysfunction. OBJECTIVE: To identify how peri-articular ...