Browsing Centre for Experimental Medicine and Rheumatology (EMR) by Title
Now showing items 213-232 of 471
-
Increased frequency of circulating IL-21 producing Th-cells in patients with granulomatosis with polyangiitis (GPA).
(2013)INTRODUCTION: The present study aimed to explore a possible role for IL-21 producing Th-cells in the immunopathogenesis of granulomatosis with polyangiitis (GPA). METHODS: Peripheral blood from 42 GPA patients in remission ... -
Increased hip adduction during running is associated with patellofemoral pain and differs between males and females: A case-control study.
(2019-06-25)Patellofemoral pain is common amongst recreational runners and associated with altered running kinematics. However, it is currently unclear how sex may influence kinematic differences previously reported in runners with ... -
Increased plasma levels of Gas6 and its soluble tyrosine kinase receptors Mer and Axl are associated with immunological activity and severity of lupus nephritis.
(2020-06-04)OBJECTIVES: Growth arrest-specific 6 (Gas6) and its receptors have been shown to play a crucial role in the homeostasis of the innate immune system by regulating apoptosis and inflammation. We aimed to verify whether an ... -
Influence of plasma processing on recovery and analysis of circulating nucleic acids.
(2013)Circulating nucleic acids (CNAs) are under investigation as a liquid biopsy in cancer. However there is wide variation in blood processing and methods for isolation of circulating free DNA (cfDNA) and microRNAs (miRNAs). ... -
Influence of the age at diagnosis in the disease expression of primary Sjögren syndrome. Analysis of 12,753 patients from the Sjögren Big Data Consortium.
(2021)OBJECTIVES: To analyse how the main components of the disease phenotype (sicca symptoms, diagnostic tests, immunological markers and systemic disease) can be driven by the age at diagnosis of primary Sjögren's syndrome ... -
Integrating physical activity promotion into UK medical school curricula: testing the feasibility of an educational tool developed by the Faculty of Sports and Exercise Medicine.
(2020)Background: At present education on exercise medicine and physical activity (PA) promotion does not feature heavily within the medical curriculum. Objectives: The purpose of this study was to test the feasibility of a ... -
Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages.
(Nature Research, 2014-01-15)Tuned and distinct responses of macrophages and dendritic cells to Toll-like receptor 4 (TLR4) activation induced by lipopolysaccharide (LPS) underpin the balance between innate and adaptive immunity. However, the molecule(s) ... -
Interleukin-36 family dysregulation drives joint inflammation and therapy response in psoriatic arthritis.
(2020-04-01)OBJECTIVES: IL-36 agonists are pro-inflammatory cytokines involved in the pathogenesis of psoriasis. However, their role in the pathogenesis of arthritis and treatment response to DMARDs in PsA remains uncertain. Therefore, ... -
Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome.
(1997-01-06)Interleukin-4 (IL-4) provides support for humoral immune responses through upregulation of T helper (Th) type 2 cell differentiation, but it is not known whether IL-4 promotes antibody-mediated autoimmune diseases such as ... -
Intranasal peptide-induced tolerance and linked suppression: consequences of complement deficiency.
(2015-01)A role for complement, particularly the classical pathway, in the regulation of immune responses is well documented. Deficiencies in C1q or C4 predispose to autoimmunity, while deficiency in C3 affects the suppression of ...