Browsing Centre for Experimental Medicine and Rheumatology (EMR) by Title
Now showing items 172-191 of 471
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The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts' Consensus.
(2021-02)Autoimmune diseases (AIDs) share similar serological, clinical, and radiological findings, but, behind these common features, there are different pathogenic mechanisms, immune cells dysfunctions, and targeted organs. In ... -
Guidelines for biomarkers in autoimmune rheumatic diseases - evidence based analysis.
(Elsevier B.V., 2019-01)Autoimmune rheumatic diseases are characterised by an abnormal immune system response, complement activation, cytokines dysregulation and inflammation. In last years, despite many progresses in managing these patients, it ... -
Heterogeneity of Human Mast Cells With Respect to MRGPRX2 Receptor Expression and Function.
(Frontiers Media SA, 2019-07-03)Mast cells and their mediators play a role in the control of homeostasis and in the pathogenesis of several disorders. The concept of rodent mast cell heterogeneity, initially established in the mid-1960s has been extended ... -
High pathogenic potential of low-affinity autoantibodies in experimental autoimmune hemolytic anemia.
(1999-12-06)To assess the potency of low-affinity anti-red blood cell (RBC) autoantibodies in the induction of anemia, we generated an immunoglobulin (Ig)G2a class-switch variant of a 4C8 IgM anti-mouse RBC autoantibody, and compared ... -
High volume image guided injections and structured rehabilitation in shoulder impingement syndrome: a retrospective study.
(2015-07)BACKGROUND: the aim was to establish the effect of a high volume-image guided injection and structured rehabilitation (HVIGI&SR) on both pain and function in shoulder impingement syndrome (SIS). METHODS: 44 participants ... -
HIV-1 Nef promotes migration and chemokine synthesis of human basophils and mast cells through the interaction with CXCR4.
(2016)BACKGROUND: The Nef protein can be detected in plasma of HIV-1-infected patients and plays a role in the pathogenesis of HIV-1. Nef produced during the early stages of infection is fundamental in creating the ideal environment ... -
How immunological profile drives clinical phenotype of primary Sjögren's syndrome at diagnosis: analysis of 10,500 patients (Sjögren Big Data Project).
(2018-08-14)OBJECTIVES: To evaluate the influence of the main immunological markers on the disease phenotype at diagnosis in a large international cohort of patients with primary Sjögren's syndrome (SjS). METHODS: The Big Data Sjögren ... -
Human mast cells and basophils-How are they similar how are they different?
(2018-03)Mast cells and basophils are key contributors to allergies and other inflammatory diseases since they are the most prominent source of histamine as well as numerous additional inflammatory mediators which drive inflammatory ...