dc.contributor.author | Juffermans, NP | en_US |
dc.contributor.author | Gözden, T | en_US |
dc.contributor.author | Brohi, K | en_US |
dc.contributor.author | Davenport, R | en_US |
dc.contributor.author | Acker, JP | en_US |
dc.contributor.author | Reade, MC | en_US |
dc.contributor.author | Maegele, M | en_US |
dc.contributor.author | Neal, MD | en_US |
dc.contributor.author | Spinella, PC | en_US |
dc.date.accessioned | 2024-07-22T10:47:07Z | |
dc.date.available | 2024-01-11 | en_US |
dc.date.issued | 2024-02-13 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/98304 | |
dc.description.abstract | Improvements have been made in optimizing initial care of trauma patients, both in prehospital systems as well as in the emergency department, and these have also favorably affected longer term outcomes. However, as specific treatments for bleeding are largely lacking, many patients continue to die from hemorrhage. Also, major knowledge gaps remain on the impact of tissue injury on the host immune and coagulation response, which hampers the development of interventions to treat or prevent organ failure, thrombosis, infections or other complications of trauma. Thereby, trauma remains a challenge for intensivists. This review describes the most pressing research questions in trauma, as well as new approaches to trauma research, with the aim to bring improved therapies to the bedside within the twenty-first century. | en_US |
dc.format.extent | 45 - ? | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Crit Care | en_US |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | |
dc.subject | Future of care | en_US |
dc.subject | Research methodology | en_US |
dc.subject | Therapies | en_US |
dc.subject | Trauma | en_US |
dc.subject | Humans | en_US |
dc.subject | Emergency Medical Services | en_US |
dc.subject | Hemorrhage | en_US |
dc.subject | Blood Coagulation | en_US |
dc.subject | Emergency Service, Hospital | en_US |
dc.subject | Wounds and Injuries | en_US |
dc.title | Transforming research to improve therapies for trauma in the twenty-first century. | en_US |
dc.type | Article | |
dc.rights.holder | © The Author(s) 2024. | |
dc.identifier.doi | 10.1186/s13054-024-04805-6 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/38350971 | en_US |
pubs.issue | 1 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 28 | en_US |
dcterms.dateAccepted | 2024-01-11 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |