Bioorthogonal Swarming: In Situ Generation of Dendrimers
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Volume
142
Pagination
21615 - 21621
Publisher
DOI
10.1021/jacs.0c07869
Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Issue
ISSN
0002-7863
Metadata
Show full item recordAbstract
With the aid of bioorthogonal chemistry, we demonstrate the fabrication of synthetic dendrimers in situ around living cells. Using tetrazine dienophile and aminooxyl/hydrazide aldehyde chemistries, the density of functional groups on the dendrimers exponentially amplified intensities of fluorescent markers in antibody-targeted live cell imaging. This novel “swarming” approach highlights the power of bioorthogonal chemistry and provides a route to non-natural chemical structures on cells, paving the way for the generation of various artificial cellular nanostructures and scaffolds.
Authors
Zhang, Y; Ucuncu, M; Gambardella, A; Baibek, A; Geng, J; Zhang, S; Clavadetscher, J; Litzen, I; Bradley, M; Lilienkampf, ACollections
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