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Accelarated immune ageing is associated with COVID-19 disease severity.
(2024-01-11)BACKGROUND: The striking increase in COVID-19 severity in older adults provides a clear example of immunesenescence, the age-related remodelling of the immune system. To better characterise the association between convalescent ... -
Age stratified, matched comparison of unicompartmental and total knee replacement.
(2020-10)BACKGROUND: Unicompartmental knee replacement (UKR) tends to provide better function but has a higher revision rate than total knee replacement (TKR). The aim was to determine if this occurred in all age groups. METHODS: ... -
Alternative developmental and transcriptomic responses to host plant water limitation in a butterfly metapopulation.
(2022-11)Predicting how climate change affects biotic interactions poses a challenge. Plant-insect herbivore interactions are particularly sensitive to climate change, as climate-induced changes in plant quality cascade into the ... -
Alternative splicing in seasonal plasticity and the potential for adaptation to environmental change.
(2022-02-08)Seasonal plasticity is accomplished via tightly regulated developmental cascades that translate environmental cues into trait changes. Little is known about how alternative splicing and other posttranscriptional molecular ... -
Amino Acids Whose Intracellular Levels Change Most During Aging Alter Chronological Life Span of Fission Yeast.
(Oxford University Press, 2020-11-03)Amino acid deprivation or supplementation can affect cellular and organismal life span, but we know little about the role of concentration changes in free, intracellular amino acids during aging. Here, we determine free ... -
Antibacterial efficacy of indigenous Pakistani honey against extensively drug-resistant clinical isolates of Salmonella enterica serovar Typhi: an alternative option to combat antimicrobial resistance
(BMC, 2023-02-08)Abstract Background Extensively drug-resistant (XDR) Salmonella enterica serovar Typhi (S. Typhi) poses a grave threat to public health due to increased mortality and morbidity caused by typhoid fever. Honey is a promising ... -
Author Correction: Multivalent interactions facilitate motor-dependent protein accumulation at growing microtubule plus-ends
(Nature Research, 2023-03-15) -
B-cell-specific checkpoint molecules that regulate anti-tumour immunity.
(2023-07)The role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour growth1,2. Here, using high-throughput flow cytometry ... -
Biallelic CACNA2D1 loss-of-function variants cause early-onset developmental epileptic encephalopathy.
(Oxford University Press, 2022-03-16)Voltage-gated calcium (CaV) channels form three subfamilies (CaV1-3). The CaV1 and CaV2 channels are heteromeric, consisting of an α1 pore-forming subunit, associated with auxiliary CaVβ and α2δ subunits. The α2δ subunits ... -
Bioinspired Bi2O3-ZrO2 nanocomposite heterojunction as energy storage material and high-performance electrocatalyst for water oxidation
(Springer, 2024-01-13)Phyto-mediated nanocomposite materials possess significant potential in morphological control as well as in electrocatalytic activity, which is the main reason for steered interest in the design of new materials for their ... -
A bovine miRNA, bta-miR-154c, withstands in vitro human digestion but does not affect cell viability of colorectal human cell lines after transfection
(Wiley Open Access, 2022-03-23)Colorectal cancer (CRC) is the third most frequent human cancer with over 1.3 million new cases globally. CRC is a complex disease caused by interactions between genetic and environmental factors; in particular, high ... -
Brain webs for brane webs
(2022-10-10)We propose a new technique for classifying 5d Superconformal Field Theories arising from brane webs in Type IIB String Theory, using technology from Machine Learning to identify different webs giving rise to the same theory. ... -
Case Review: Whole-Exome Sequencing Analyses Identify Carriers of a Known Likely Pathogenic Intronic BRCA1 Variant in Ovarian Cancer Cases Clinically Negative for Pathogenic BRCA1 and BRCA2 Variants
(MDPI, 2022-04-15)Background: Detecting pathogenic intronic variants resulting in aberrant splicing remains a challenge in routine genetic testing. We describe germline whole-exome sequencing (WES) analyses and apply in silico predictive ... -
Cell-type specialization is encoded by specific chromatin topologies.
(2021-11)The three-dimensional (3D) structure of chromatin is intrinsically associated with gene regulation and cell function1-3. Methods based on chromatin conformation capture have mapped chromatin structures in neuronal systems ... -
Characterising cancer-associated fibroblast heterogeneity in non-small cell lung cancer: a systematic review and meta-analysis.
(2021-02-12)Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with evidence suggesting they represent a heterogeneous population. This study summarises the prognostic role of all proteins characterised ...