dc.contributor.author | Carrillo-Baltodano, AM | en_US |
dc.contributor.author | Donnellan, RD | en_US |
dc.contributor.author | Williams, EA | en_US |
dc.contributor.author | Jékely, G | en_US |
dc.contributor.author | Martín-Durán, JM | en_US |
dc.date.accessioned | 2024-06-19T08:52:43Z | |
dc.date.available | 2024-02-02 | en_US |
dc.date.issued | 2024-02-21 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/97519 | |
dc.description.abstract | BACKGROUND: The evolutionary origins of animal nervous systems remain contentious because we still have a limited understanding of neural development in most major animal clades. Annelids - a species-rich group with centralised nervous systems - have played central roles in hypotheses about the origins of animal nervous systems. However, most studies have focused on adults of deeply nested species in the annelid tree. Recently, Owenia fusiformis has emerged as an informative species to reconstruct ancestral traits in Annelida, given its phylogenetic position within the sister clade to all remaining annelids. METHODS: Combining immunohistochemistry of the conserved neuropeptides FVamide-lir, RYamide-lir, RGWamide-lir and MIP-lir with gene expression, we comprehensively characterise neural development from larva to adulthood in Owenia fusiformis. RESULTS: The early larval nervous system comprises a neuropeptide-rich apical organ connected through peripheral nerves to a prototroch ring and the chaetal sac. There are seven sensory neurons in the prototroch. A bilobed brain forms below the apical organ and connects to the ventral nerve cord of the developing juvenile. During metamorphosis, the brain compresses, becoming ring-shaped, and the trunk nervous system develops several longitudinal cords and segmented lateral nerves. CONCLUSIONS: Our findings reveal the formation and reorganisation of the nervous system during the life cycle of O. fusiformis, an early-branching annelid. Despite its apparent neuroanatomical simplicity, this species has a diverse peptidergic nervous system, exhibiting morphological similarities with other annelids, particularly at the larval stages. Our work supports the importance of neuropeptides in animal nervous systems and highlights how neuropeptides are differentially used throughout development. | en_US |
dc.format.extent | 3 - ? | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Neural Dev | en_US |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | |
dc.subject | Annelid | en_US |
dc.subject | Larvae | en_US |
dc.subject | Nervous system | en_US |
dc.subject | Neuropeptides | en_US |
dc.subject | Animals | en_US |
dc.subject | Phylogeny | en_US |
dc.subject | Annelida | en_US |
dc.subject | Nervous System | en_US |
dc.subject | Polychaeta | en_US |
dc.subject | Neuropeptides | en_US |
dc.subject | Larva | en_US |
dc.title | The development of the adult nervous system in the annelid Owenia fusiformis. | en_US |
dc.type | Article | |
dc.identifier.doi | 10.1186/s13064-024-00180-8 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/38383501 | en_US |
pubs.issue | 1 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 19 | en_US |
dcterms.dateAccepted | 2024-02-02 | en_US |
rioxxterms.funder | Default funder | en_US |
rioxxterms.identifier.project | Default project | en_US |