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    Plasma proteins predict conversion to dementia from prodromal disease. 
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    • Plasma proteins predict conversion to dementia from prodromal disease.
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    Plasma proteins predict conversion to dementia from prodromal disease.

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    Plasma proteins predict conversion to dementia from prodromal disease.pdf (563.7Kb)
    Volume
    10
    Pagination
    799 - 807.e2
    DOI
    10.1016/j.jalz.2014.05.1749
    Journal
    Alzheimers Dement
    Issue
    6
    Metadata
    Show full item record
    Abstract
    BACKGROUND: The study aimed to validate previously discovered plasma biomarkers associated with AD, using a design based on imaging measures as surrogate for disease severity and assess their prognostic value in predicting conversion to dementia. METHODS: Three multicenter cohorts of cognitively healthy elderly, mild cognitive impairment (MCI), and AD participants with standardized clinical assessments and structural neuroimaging measures were used. Twenty-six candidate proteins were quantified in 1148 subjects using multiplex (xMAP) assays. RESULTS: Sixteen proteins correlated with disease severity and cognitive decline. Strongest associations were in the MCI group with a panel of 10 proteins predicting progression to AD (accuracy 87%, sensitivity 85%, and specificity 88%). CONCLUSIONS: We have identified 10 plasma proteins strongly associated with disease severity and disease progression. Such markers may be useful for patient selection for clinical trials and assessment of patients with predisease subjective memory complaints.
    Authors
    Hye, A; Riddoch-Contreras, J; Baird, AL; Ashton, NJ; Bazenet, C; Leung, R; Westman, E; Simmons, A; Dobson, R; Sattlecker, M
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/8805
    Collections
    • Centre for Neuroscience, Surgery and Trauma [993]
    Language
    eng
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