dc.contributor.author | Malacrida, B | en_US |
dc.contributor.author | Pearce, OMT | en_US |
dc.contributor.author | Balkwill, FR | en_US |
dc.date.accessioned | 2023-04-03T14:10:56Z | |
dc.date.issued | 2022-03-18 | en_US |
dc.identifier.uri | https://qmro.qmul.ac.uk/xmlui/handle/123456789/85530 | |
dc.description.abstract | Three-dimensional (3D), multicellular invitro models provide a useful platform for studying human cancer biology, particularly through deconvolution of the tumor microenvironment, or where animal models do not recapitulate the human condition. Here, we detail a protocol for building human multicellular models made of patient-derived primary cells and malignant cell lines, which recapitulate features of the tumor microenvironment. This protocol is optimized for building 3D models of high-grade serous ovarian cancer omental metastasis but can be adapted for modeling other cancers. For complete details on the use and execution of this profile, please refer to Delaine-Smith et al. (2021) and Malacrida et al. (2021). | en_US |
dc.format.extent | 101086 - ? | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | STAR Protoc | en_US |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject | Cancer | en_US |
dc.subject | Cell Biology | en_US |
dc.subject | Cell culture | en_US |
dc.subject | Cell isolation | en_US |
dc.subject | Animals | en_US |
dc.subject | Cell Line, Tumor | en_US |
dc.subject | Female | en_US |
dc.subject | Humans | en_US |
dc.subject | Ovarian Neoplasms | en_US |
dc.subject | Peritoneal Neoplasms | en_US |
dc.subject | Tumor Microenvironment | en_US |
dc.title | Building invitro 3D human multicellular models of high-grade serous ovarian cancer. | en_US |
dc.type | Article | |
dc.identifier.doi | 10.1016/j.xpro.2021.101086 | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/35072115 | en_US |
pubs.issue | 1 | en_US |
pubs.notes | Not known | en_US |
pubs.publication-status | Published online | en_US |
pubs.volume | 3 | en_US |