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    Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation. 
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    • Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation.
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    • Centre for Neuroscience, Surgery and Trauma
    • Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation.
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    Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation.

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    Published version (3.682Mb)
    Volume
    10
    Pagination
    1626 - 1638
    DOI
    10.1016/j.celrep.2015.02.012
    Journal
    Cell Rep
    Issue
    9
    Metadata
    Show full item record
    Abstract
    Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory diseases. Although the role of toll-like receptor 4 (TLR4) in microglia's inflammatory response is fully acknowledged, little is known about endogenous ligands that trigger TLR4 activation. Here, we report that galectin-3 (Gal3) released by microglia acts as an endogenous paracrine TLR4 ligand. Gal3-TLR4 interaction was further confirmed in a murine neuroinflammatory model (intranigral lipopolysaccharide [LPS] injection) and in human stroke subjects. Depletion of Gal3 exerted neuroprotective and anti-inflammatory effects following global brain ischemia and in the neuroinflammatory LPS model. These results suggest that Gal3-dependent-TLR4 activation could contribute to sustained microglia activation, prolonging the inflammatory response in the brain.
    Authors
    Burguillos, MA; Svensson, M; Schulte, T; Boza-Serrano, A; Garcia-Quintanilla, A; Kavanagh, E; Santiago, M; Viceconte, N; Oliva-Martin, MJ; Osman, AM
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/8528
    Collections
    • Centre for Neuroscience, Surgery and Trauma [976]
    Language
    eng
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