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iTACTIC - implementing Treatment Algorithms for the Correction of Trauma-Induced Coagulopathy: study protocol for a multicentre, randomised controlled trial.
Baksaas-Aasen, K; Gall, L; Eaglestone, S; Rourke, C; Juffermans, NP; Goslings, JC; Naess, PA; van Dieren, S; Ostrowski, SR; Stensballe, J (2017-10-18)BACKGROUND: Traumatic injury is the fourth leading cause of death globally. Half of all trauma deaths are due to bleeding and most of these will occur within 6 h of injury. Haemorrhagic shock following injury has been shown ... -
Prothrombin complex concentrate (PCC) for treatment of trauma-induced coagulopathy: systematic review and meta-analyses.
Hannadjas, I; James, A; Davenport, R; Lindsay, C; Brohi, K; Cole, E (2023-11-02)BACKGROUND: Trauma-induced coagulopathy (TIC) is common in trauma patients with major hemorrhage. Prothrombin complex concentrate (PCC) is used as a potential treatment for the correction of TIC, but the efficacy, timing, ... -
Platelet reactivity influences clot structure as assessed by fractal analysis of viscoelastic properties.
Knowles, RB; Lawrence, MJ; Ferreira, PM; Hayman, MA; D'Silva, LA; Stanford, SN; Sabra, A; Tucker, AT; Hawkins, KM; Williams, PR (2018-03)Despite the interwoven nature of platelet activation and the coagulation system in thrombosis, few studies relate both analysis of protein and cellular parts of coagulation in the same population. In the present study, we ...