Signalling Properties of Inositol Polyphosphates
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Volume
25
Publisher
Publisher URL
DOI
10.3390/molecules25225281
Journal
MOLECULES
Issue
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Show full item recordAbstract
Several studies have identified specific signalling functions for inositol polyphosphates
(IPs) in different cell types and have led to the accumulation of new information regarding their
cellular roles as well as new insights into their cellular production. These studies have revealed
that interaction of IPs with several proteins is critical for stabilization of protein complexes and for
modulation of enzymatic activity. This has not only revealed their importance in regulation of several
cellular processes but it has also highlighted the possibility of new pharmacological interventions in
multiple diseases, including cancer. In this review, we describe some of the intracellular roles of IPs
and we discuss the pharmacological opportunities that modulation of IPs levels can provide.