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Signalling Properties of Inositol Polyphosphates

dc.contributor.authorMaffucci, T
dc.contributor.authorFalasca, M
dc.date.accessioned2021-06-04T11:17:13Z
dc.date.available2020-11-04
dc.date.available2021-06-04T11:17:13Z
dc.date.issued2020-11-12
dc.identifier.citationMaffucci, T.; Falasca, M. Signalling Properties of Inositol Polyphosphates. Molecules 2020, 25, 5281. https://doi.org/10.3390/molecules25225281en_US
dc.identifier.otherARTN 5281
dc.identifier.otherARTN 5281
dc.identifier.otherARTN 5281
dc.identifier.urihttps://qmro.qmul.ac.uk/xmlui/handle/123456789/72323
dc.description.abstractSeveral studies have identified specific signalling functions for inositol polyphosphates (IPs) in different cell types and have led to the accumulation of new information regarding their cellular roles as well as new insights into their cellular production. These studies have revealed that interaction of IPs with several proteins is critical for stabilization of protein complexes and for modulation of enzymatic activity. This has not only revealed their importance in regulation of several cellular processes but it has also highlighted the possibility of new pharmacological interventions in multiple diseases, including cancer. In this review, we describe some of the intracellular roles of IPs and we discuss the pharmacological opportunities that modulation of IPs levels can provide.en_US
dc.publisherMDPIen_US
dc.relation.ispartofMOLECULES
dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.subjectinositol phosphatesen_US
dc.subjectcell signalingen_US
dc.subjectexperimental pharmacologyen_US
dc.subjectpleckstrin homology domainen_US
dc.subjectinositol 1en_US
dc.subject3en_US
dc.subject4en_US
dc.subject5en_US
dc.subject6-pentakisphosphateen_US
dc.subjectinositol 1en_US
dc.subject2en_US
dc.subject3en_US
dc.subject4en_US
dc.subject5en_US
dc.subject6-hexakisphosphateen_US
dc.titleSignalling Properties of Inositol Polyphosphatesen_US
dc.typeArticleen_US
dc.rights.holder© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
dc.identifier.doi10.3390/molecules25225281
pubs.author-urlhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000594122300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=612ae0d773dcbdba3046f6df545e9f6aen_US
pubs.issue22en_US
pubs.notesNot knownen_US
pubs.publication-statusPublisheden_US
pubs.publisher-urlhttp://doi.org/10.3390/molecules25225281
pubs.volume25en_US
rioxxterms.funderDefault funderen_US
rioxxterms.identifier.projectDefault projecten_US


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