dc.contributor.author | Burguillos, MA | |
dc.contributor.author | Svensson, M | |
dc.contributor.author | Schulte, T | |
dc.contributor.author | Boza-Serrano, A | |
dc.contributor.author | Garcia-Quintanilla, A | |
dc.contributor.author | Kavanagh, E | |
dc.contributor.author | Santiago, M | |
dc.contributor.author | Viceconte, N | |
dc.contributor.author | Oliva-Martin, MJ | |
dc.contributor.author | Osman, AM | |
dc.contributor.author | Salomonsson, E | |
dc.contributor.author | Amar, L | |
dc.contributor.author | Persson, A | |
dc.contributor.author | Blomgren, K | |
dc.contributor.author | Achour, A | |
dc.contributor.author | Englund, E | |
dc.contributor.author | Leffler, H | |
dc.contributor.author | Venero, JL | |
dc.contributor.author | Joseph, B | |
dc.contributor.author | Deierborg, T | |
dc.date.accessioned | 2015-03-26T09:01:27Z | |
dc.date.issued | 2015-03-04 | |
dc.identifier.uri | http://qmro.qmul.ac.uk/xmlui/handle/123456789/7074 | |
dc.description.abstract | Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory diseases. Although the role of toll-like receptor 4 (TLR4) in microglia's inflammatory response is fully acknowledged, little is known about endogenous ligands that trigger TLR4 activation. Here, we report that galectin-3 (Gal3) released by microglia acts as an endogenous paracrine TLR4 ligand. Gal3-TLR4 interaction was further confirmed in a murine neuroinflammatory model (intranigral lipopolysaccharide [LPS] injection) and in human stroke subjects. Depletion of Gal3 exerted neuroprotective and anti-inflammatory effects following global brain ischemia and in the neuroinflammatory LPS model. These results suggest that Gal3-dependent-TLR4 activation could contribute to sustained microglia activation, prolonging the inflammatory response in the brain. | |
dc.language | ENG | |
dc.relation.isreplacedby | 123456789/8528 | |
dc.relation.isreplacedby | http://qmro.qmul.ac.uk/jspui/handle/123456789/8528 | |
dc.title | Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation. | |
dc.identifier.doi | 10.1016/j.celrep.2015.02.012 | |
dc.relation.isPartOf | Cell Rep | |
pubs.author-url | http://www.ncbi.nlm.nih.gov/pubmed/25753426 | |
pubs.author-url | http://www.ncbi.nlm.nih.gov/pubmed/25753426 | |