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"This is the peer reviewed version of the following article: Alliouachene, S., Kieswich, J.E., Bilanges, B., McCafferty, K., Thiemermann, C., Vanhaesebroeck, B. and Yaqoob, M.M. (2021), Uninephrectomy and class II PI3K‐C2β inactivation synergistically protect against obesity, insulin resistance and liver steatosis in mice. American Journal of Transplantation. https://doi.org/10.1111/ajt.16470. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."