Cancer cells, on your histone marks, get SETDB1, silence retrotransposons, and go!
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Volume
216
Pagination
3429 - 3431
DOI
10.1083/jcb.201710068
Journal
J Cell Biol
Issue
Metadata
Show full item recordAbstract
Cancer cells thrive on genetic and epigenetic changes that confer a selective advantage but also need strategies to avoid immune recognition. In this issue, Cuellar et al. (2017. J. Cell Biol https://doi.org/10.1083/jcb.201612160) find that the histone methyltransferase SETDB1 enables acute myeloid leukemia cells to evade sensing of retrotransposons by innate immune receptors.
Authors
Robbez-Masson, L; Tie, CHC; Rowe, HMCollections
- Centre for Immunobiology [1121]