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    Developing Biomarkers for MS. 
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    Developing Biomarkers for MS.

    Volume
    26
    Pagination
    179 - 194
    DOI
    10.1007/7854_2014_362
    Journal
    Curr Top Behav Neurosci
    ISSN
    1866-3370
    Metadata
    Show full item record
    Abstract
    Existing clinical outcomes of disease activity, including relapse rates, are inherently insensitive to the underlying pathological process in MS. Moreover, it is extremely difficult to measure clinical disability in patients, which is often a retrospective assessment, and definitely not within the time frame of a clinical trial. Biomarkers , conversely are more specific for a pathologic process and if used correctly can prove invaluable in the diagnosis, stratification and monitoring of disease activity, including any subclinical activity which is not visible to the naked eye. In this chapter, we discuss the development of neurofilaments as surrogate outcomes of disability in MS. The validation and qualification are vital steps in biomarker development and to gaining acceptance in scientific community, and the pitfalls leading up to this are also discussed.
    Authors
    Gnanapavan, S; Giovannoni, G
    URI
    http://qmro.qmul.ac.uk/xmlui/handle/123456789/6325
    Collections
    • Centre for Neuroscience, Surgery and Trauma [976]
    Language
    eng
    Copyright statements
    © Springer International Publishing Switzerland 2014
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