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Now showing items 71-80 of 115
10 years into the resurgence of covalent drugs.
(2021-01)
In the first decade of targeted covalent inhibition, scientists have successfully reversed the previous trend that had impeded the use of covalent inhibition in drug development. Successes in the clinic, mainly in the field ...
Blocking Kallikrein 6 promotes developmental myelination
(Wiley, 2022-03)
<jats:title>Abstract</jats:title><jats:p>Kallikrein related peptidase 6 (Klk6) is a secreted serine protease highly expressed in oligodendrocytes and implicated in demyelinating conditions. To gain insights into the ...
A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion.
(2022-12-14)
Pancreatic cancer has the lowest survival rate of all common cancers due to late diagnosis and limited treatment options. Serine hydrolases are known to mediate cancer progression and metastasis through initiation of ...
Beyond targeted protein degradation: LD·ATTECs clear cellular lipid droplets
(Springer Science and Business Media LLC, 2021-09)
A curcumin direct protein biosensor for cell-free prototyping.
(2022)
In synthetic biology, biosensors are routinely coupled with a gene expression system for detecting small molecules and physical signals. We reveal a fluorescent complex, based on the interaction of an Escherichia coli ...