Browsing Biology by Subject "Zebrafish"
Now showing items 1-2 of 2
-
Digenic inheritance involving a muscle-specific protein kinase and the giant titin protein causes a skeletal muscle myopathy.
(Springer Nature, 2024-03-01)In digenic inheritance, pathogenic variants in two genes must be inherited together to cause disease. Only very few examples of digenic inheritance have been described in the neuromuscular disease field. Here we show that ... -
mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity.
(2022-09-29)Necrosis of macrophages in the granuloma, the hallmark immunological structure of tuberculosis, is a major pathogenic event that increases host susceptibility. Through a zebrafish forward genetic screen, we identified the ...