Browsing Biology by Subject "Substrate Specificity"
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Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs.
(2012-11)Nitroheterocyclic prodrugs are used to treat infections caused by Trypanosoma cruzi and Trypanosoma brucei. A key component in selectivity involves a specific activation step mediated by a protein homologous with type I ...