Browsing Biology by Author "Ramakrishnan, L"

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    • mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity. 

      Pagán, AJ; Lee, LJ; Edwards-Hicks, J; Moens, CB; Tobin, DM; Busch-Nentwich, EM; Pearce, EL; Ramakrishnan, L (2022-09-29)
      Necrosis of macrophages in the granuloma, the hallmark immunological structure of tuberculosis, is a major pathogenic event that increases host susceptibility. Through a zebrafish forward genetic screen, we identified the ...