Browsing Biology by Author "Miller, AK"
Now showing items 1-6 of 6
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Blocking Kallikrein 6 promotes developmental myelination
Yoon, H; Triplet, EM; Simon, WL; Choi, C; Kleppe, LS; De Vita, E; Miller, AK; Scarisbrick, IA (Wiley, 2022-03)<jats:title>Abstract</jats:title><jats:p>Kallikrein related peptidase 6 (Klk6) is a secreted serine protease highly expressed in oligodendrocytes and implicated in demyelinating conditions. To gain insights into the ... -
Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity
De Vita, E; Schüler, P; Lovell, S; Lohbeck, J; Kullmann, S; Rabinovich, E; Sananes, A; Heßling, B; Hamon, V; Papo, N (American Chemical Society (ACS), 2018-10-11) -
A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion.
Zhang, L; Lovell, S; De Vita, E; Jagtap, PKA; Lucy, D; Goya Grocin, A; Kjær, S; Borg, A; Hennig, J; Miller, AK (2022-12-14)Pancreatic cancer has the lowest survival rate of all common cancers due to late diagnosis and limited treatment options. Serine hydrolases are known to mediate cancer progression and metastasis through initiation of ... -
A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering
Sananes, A; Cohen, I; Shahar, A; Hockla, A; De Vita, E; Miller, AK; Radisky, ES; Papo, N (Elsevier BV, 2018-08) -
Rapid detection of 2-hydroxyglutarate in frozen sections of IDH mutant tumors by MALDI-TOF mass spectrometry
Longuespée, R; Wefers, AK; De Vita, E; Miller, AK; Reuss, DE; Wick, W; Herold-Mende, C; Kriegsmann, M; Schirmacher, P; von Deimling, A (Springer Science and Business Media LLC, 2018-12) -
Synthesis and Structure‐Activity Relationships of N‐(4‐Benzamidino)‐Oxazolidinones: Potent and Selective Inhibitors of Kallikrein‐Related Peptidase 6
De Vita, E; Smits, N; Hurk, H; Beck, EM; Hewitt, J; Baillie, G; Russell, E; Pannifer, A; Hamon, V; Morrison, A (Wiley, 2020-01-07)