Browsing Biology by Author "Hall, BS"
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Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs.
Hall, BS; Meredith, EL; Wilkinson, SR (2012-11)Nitroheterocyclic prodrugs are used to treat infections caused by Trypanosoma cruzi and Trypanosoma brucei. A key component in selectivity involves a specific activation step mediated by a protein homologous with type I ...